Prediction of survival after liver transplantation (LT) for hepatocellular carcinoma (HCC) using the TNM staging classification modified for LT: Validation in a French cohort

Impact of tumour differentiation to select patients before liver transplantation for hepatocellular carcinoma

“…The predictive value of tumour differentiation has been reported in several series (10–12, 35, 36) as well as in a recent meta‐analysis of 1198 cases of LT for HCC (37). In our study, pre‐LT determination of tumour differentiation was available in a limited number of patients, and multivariate Cox analysis of predictors of tumour‐free survival was therefore carried out using pathological records of surgical explants.…”

Prediction of hepatocellular carcinoma recurrence after liver transplantation: Comparison of four explant‐based prognostic models

“…The Decaens model, 21 which included tumour differentiation as an additional variable to size and number of tumours also performed reasonably well but did not performed better than the "Up to seven" model although the predictive value of tumour differentiation has been reported in several series or meta-analysis. [25][26][27][28][29][30] Demonstration of the beneficial impact of tumour differentiation on prediction of recurrence might have been hampered by the small proportion of poorly differentiated tumours in our external cohort (4.6%).…”