Prediction of survival with combining quantitative ¹⁸F‐FDG PET/CT and DW‐MRI parameters in sinonasal malignancies

Abstract

Background We aimed to establish the prognostic value of 18F‐fluoro‐deoxy‐glucose positron emission/CT (18F‐FDG PET/CT) and diffusion‐weighted (DW) MRI in determining overall survival (OS), progression‐free survival (PFS), and distant metastasis‐free survival (DMFS) of sinonasal malignancies. Methods Sixty‐eight patients with sinonasal cancer who underwent both pretreatment 18F‐FDG PET/CT scan and head‐neck MRI from January 2009 through August 2017 were retrospectively reviewed. Kaplan‐Meier survival analysis of 18F‐FDG PET/CT and DW‐MRI parameters were performed for OS, PFS, and DMFS. Results Cox regression analysis determined that all the quantitative 18F‐FDG PET/CT and DW‐MRI parameters were independently correlated with PFS, DMFS, and OS (P < .05). After controlling for imaging variables, perineural invasion (P = .02) and ill‐defined margin (P = .02) were found to be significantly correlated with shorter OS; while the perineural invasion was significantly correlated with shorter PFS (P = .02). Conclusions The pretreatment DW‐MRI and 18F‐FDG PET/CT parameters could be substantial surrogate markers for sinonasal malignancies.

Hybrid positron emission tomography imaging for initial staging of sinonasal tumors: Total lesion glycolysis as prognosticator of treatment response

“…At time of diagnosis, lymph node metastases or DM were only present in the minority of cases, which is in line with previous studies 9,27 . Similar to other series, sinonasal melanoma and SCC were among the most frequent tumor entities 9,22,28,29 . Initial radiological staging of sinonasal tumors requires detailed information on local tumor extent, especially with regard to infiltration of the orbit and skull base.…”

“…9,27 Similar to other series, sinonasal melanoma and SCC were among the most frequent tumor entities. 9,22,28,29 Initial radiological staging of sinonasal tumors requires detailed information on local tumor extent, especially with regard to infiltration of the orbit and skull base. As represented in the AJCC cancer staging system, this information determines the T category and serves as a strong predictor of the 5-year diseasespecific survival.…”

“…This parameter is known to be variable among different tumor entities encountered in the sinonasal tract, with sinonasal undifferentiated carcinoma (SNUC) typically yielding higher uptake than olfactory neuroblastoma or adenoidcystic carcinoma 19‐21 . Additionally, a higher SUV max was reported to be associated with decreased overall survival (OS), progression‐free survival and DM‐free survival 22 …”

“…[19][20][21] Additionally, a higher SUV max was reported to be associated with decreased overall survival (OS), progressionfree survival and DM-free survival. 22 The aim of our study was (a) to assess the diagnostic accuracy of hybrid PET imaging in the initial staging of sinonasal malignancies with regard to lymph node metastases and DM and (b) to investigate other PET-based parameters for their ability to prognosticate diseasespecific and patient-specific outcome.…”

The Role of Regional Disease and Patterns of Treatment Failure in Primary Sinonasal Malignancies

“…Review of initial T classification revealed locally advanced tumors in the vast majority of all subjects (120 of 152 patients ≥ cT3, 78.9%) and adenocarcinoma, sinonasal melanoma, and SCC to be the most frequent tumor entities. [26][27][28][29] We found a low rate of both, LN metastases and DM in the initial staging. 15 LN metastases were predominantly located in ipsilateral and contralateral LN levels I and II, which confirms previous findings.…”