Prediction of the depth of invasion in superficial pharyngeal cancer: Microvessel morphological evaluation with narrowband imaging

Eguchi, Kohtaro; Matsui, Toshihiro; Mukai, Makoto; Sugimoto, Taro

doi:10.1002/hed.25935

Cited by 11 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of previous reports on ME‐NBI for pharyngeal cancer are summarized in Table 6 . 17 , 19 , 20 , 21 , 22 , 23 Pharyngeal carcinoma with B2–B3 vessels has been reported to be significantly more likely to show SEP. 17 , 21 Furthermore, there are a few reports on the correlation between B vessels and tumor thickness. 22 , 23 In this study, the tumor thickness was significantly greater in the order of B1, B2, and B3 vessels, suggesting that the thickness of the tumor, which may be a risk factor for LNM, can be predicted by observing the microvascular pattern.…”

Section: Discussionmentioning

confidence: 99%

Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society classification

et al. 2022

View full text Add to dashboard Cite

Backgrounds The pharynx has no muscularis mucosae, so it is unclear whether diagnostic techniques used for the esophagus can be applied to the pharynx. This study investigated the usefulness of magnifying endoscopy with narrowband imaging using the Japan Esophageal Society (JES) classification for predicting the depth of invasion and lymph node metastasis (LNM) in pharyngeal cancer. Methods A total of 123 superficial pharyngeal carcinoma lesions that had been observed preoperatively with magnifying endoscopy with narrowband imaging between January 2014 and June 2021 were analyzed. Predictors of subepithelial invasion (SEP) and LNM were sought based on endoscopic findings, including microvascular morphology, using the JES classification. Results The lesions were divided into carcinoma in situ ( n = 41) and SEP ( n = 82). Multivariate analysis identified B2–B3 vessels (odds ratio [OR] 6.54, 95% confidence interval [CI] 1.74–24.61, p = 0.005) and a middle/large avascular area (OR 4.15, 95% CI 1.18–14.62, p = 0.027) as independent predictors of SEP. Significant predictors of LNM were protruding type, B2–B3 vessels, middle/large avascular area, SEP, venous invasion, lymphatic invasion, and tumor thickness > 1000 μm. Median tumor thickness increased significantly in the order of B1 < B2 < B3 vessels (B1, 305 μm; B2, 1045 μm; B3, 4043 μm; p < 0.001). The LNM rates for B1, B2, and B3 vessels were 1.6% (1/63), 4.8% (2/42), and 55.6% (10/18), respectively ( p < 0.001). Conclusions Magnifying endoscopy with narrowband imaging using the JES classification could predict the depth of invasion in superficial pharyngeal carcinoma. The JES classification may contribute to the prediction of LNM, suggesting that it could serve as an alternative to tumor thickness.

show abstract

Section: Discussionmentioning

confidence: 99%

Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society classification

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Our results showed a statistically significant association between tumor thickness and CLNM (Table 3). As predictors for tumor thickness, Eguchi et al have demonstrated a significant correlation between the classification of type B vessels and tumor thickness in superficial pharyngeal cancer (20). Katada et al also have reported on the substantial correlation between the classification of type B vessels and synchronous lymph node metastasis/lymphatic invasion in superficial pharyngeal cancer (21).…”

Section: Association Between Tumor Thickness and Classification Of Ty...mentioning

confidence: 99%

“…Additionally, we classified the depth of invasion in SHNC as either EP (tumor located in the epithelium, equivalent to carcinoma in situ) or SEP (tumor involving the subepithelial layer). Tumor thickness, defined as the distance from the tumor surface to the deepest point of tumor invasion (3,20,21), was measured in the SEP tumors.…”

Section: Analysis Of Predictive Factorsmentioning

confidence: 99%

Predicting Cervical Lymph Node Metastasis Following Endoscopic Surgery in Superficial Head and Neck Carcinoma

et al. 2022

View full text Add to dashboard Cite

BackgroundEarly detection of head and neck carcinoma (HNC) as superficial HNC (SHNC) identified using recently developed optical techniques, such as magnifying endoscopy and narrow-band imaging (NBI), in combination with endoscopic surgeries enables minimally invasive treatment with favorable outcomes for HNC. This study aimed to identify the predictive factors for the rare but important clinical issue of SHNC, namely cervical lymph node metastasis (CLNM), following endoscopic resection.MethodsSixty-nine patients with SHNC who underwent endoscopic resection were enrolled in the study. Clinical data, preoperative endoscopic findings, pathological findings, and treatment outcomes were retrospectively reviewed. Because the pharyngeal mucosa lacks the muscularis mucosa, we measured tumor thickness in permanent pathology as an alternative to the depth of invasion. Correlations with the occurrence of CLNM were statistically examined.ResultsThe 5-year disease-specific survival rate was 100%. Of 69 patients, 3 (4.3%) developed CLNM. All had subepithelial but not epithelial tumors. The 0-IIa type in the macroscopic findings, type B2/B3 vessels in narrow-band imaging, tumors ≥ pathological stage T2, lymphatic invasion, positive surgical margins, and tumor thickness >1,000 μm showed significant correlations with CLNM following endoscopic resection. Furthermore, the classification of type B vessels was significantly associated with tumor thickness.ConclusionThe treatment outcomes following endoscopic resection for SHNC were favorable. The risk of CLNM following endoscopic resection in SHNC can be predicted by several preoperative endoscopic and postoperative pathological findings. Among them, the classification of type B vessels, which correlated with both tumor thickness and CLNM, might be a useful predictive factor.

show abstract

“…NBI is highly powerful, not only in differentiating nonmalignant from malignant lesions (34), but also in detecting precancerous lesions and predicting the invasive depth and thickness of pharyngeal tumors (35)(36)(37). To date, the classifications include IPCL Pattern Classification, namely, the Japan Esophageal Society Classification (JES Classification), and the NBI Classification of nasopharyngeal mucosal microvessel patterns.…”

Section: The Classifications Of Pharyngeal Lesionsmentioning

confidence: 99%

“…The Ni Classification has been used for the early diagnosis of head and neck squamous cell carcinomas (HNSCCs) and this classification also shares some common criteria with the JES Classification. Eguchi found that Va and Vb of the Ni Classification corresponded to the B1 and B2 Classification, respectively (28,36,(39)(40)(41).…”

Section: The Classifications Of Pharyngeal Lesionsmentioning

confidence: 99%

A narrative review: narrow-band imaging endoscopic classifications

Yang¹,

Liu²,

Sun³

et al. 2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

Background and Objective: With the development of endoscopic techniques, narrow-band imaging (NBI) has been widely used in the diagnosis of various types of diseases. NBI can detect mucosal lesions at an early stage and different classification strategies have been established to help clinicians in disease diagnosis. However, there is currently no consensus for the classification criteria. This report summarizes the current classifications of diseases using NBI, so as to provide a comprehensive understanding of the various manifestations of mucosal lesions under NBI, and to promote the development of more practical NBI classifications.Methods: The PubMed database was searched for English language articles published between January 1994 and November 2021 using the keywords 'narrow band imaging', 'NBI', and 'classification'.

show abstract

Prediction of the depth of invasion in superficial pharyngeal cancer: Microvessel morphological evaluation with narrowband imaging

Cited by 11 publications

References 25 publications

Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society classification

Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society classification

Predicting Cervical Lymph Node Metastasis Following Endoscopic Surgery in Superficial Head and Neck Carcinoma

A narrative review: narrow-band imaging endoscopic classifications

Contact Info

Product

Resources

About