2007
DOI: 10.1002/jps.20918
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Prediction of the Onset of Crystallization of Amorphous Sucrose Below the Calorimetric Glass Transition Temperature from Correlations with Mobility

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Cited by 76 publications
(103 citation statements)
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References 25 publications
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“…We note that the results of this study are in agreement with the results of previous study from our laboratory where we correlated the crystallization induction time with relaxation times in similar temperature ranges for a variety of single component systems. 11 The present work clearly suggests that the relaxation times and crystal growth rates measured above and below the T g do correlate for the multicomponent systems studied (also the more industrially relevant systems) and therefore extends the protocol described in the previous work to such systems.…”
Section: Discussionmentioning
confidence: 75%
See 1 more Smart Citation
“…We note that the results of this study are in agreement with the results of previous study from our laboratory where we correlated the crystallization induction time with relaxation times in similar temperature ranges for a variety of single component systems. 11 The present work clearly suggests that the relaxation times and crystal growth rates measured above and below the T g do correlate for the multicomponent systems studied (also the more industrially relevant systems) and therefore extends the protocol described in the previous work to such systems.…”
Section: Discussionmentioning
confidence: 75%
“…10 Also, our previous studies have shown that the crystallization onset times above T g were correlated and well coupled with the measured molecular mobility for several pure amorphous compounds. 11,12 Further, the same kind of correlation and coupling has been established between crystal growth rate and molecular mobility above T g for single component systems. 12 In this work, we extended this approach to test the correlation between crystal growth and molecular mobility for both pure amorphous compound, namely phenobarbital, and its solid dispersion with polymeric polyvinylpyrrolidone and a small molecule L-proline.…”
Section: Introductionmentioning
confidence: 89%
“…Most of these studies have been performed on single component systems. [126][127][128] In one particular publication, however, they included solid dispersions of phenobarbital with 8% w/w of PVP or l-proline. [129] The crystallization rates were followed using microscopy at different temperatures above Tg, and one point below Tg, after crystallization was first induced above Tg.…”
Section: The Role Of Hydrogen Bondsmentioning
confidence: 99%
“…Recent studies observed very small reorientation motions in solid dispersions showing a detailed heterogeneity of solid dispersionsanddetecting the sub-glass transition beta-relaxation as well as alpha-relaxation, which may lead to nucleation and crystal growth. Molecular mobility of the amorphous system depends, not only on its composition, but also on the manufacturing process as stated by Bhugra et al 12 . Solid dispersions exhibiting high conformational entropy and lower molecular mobility are more physically stable.…”
Section: Strategies To Avoid Drug Recrystallizationmentioning
confidence: 96%