Prediction of the three‐dimensional turbulent flow in stirred tanks

Kresta, Suzanne M.; Wood, P. E.

doi:10.1002/aic.690370314

Cited by 155 publications

(96 citation statements)

References 31 publications

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“…In the case of bioprocessing, shear stresses are present during the separation, purification, shipping, and handling of protein based products. 13 For example, processing steps involving ultrafiltration reactors, 120,121 stirred tanks, 122,123 homogenizers, 124 and pumps 53,125 induce high shear stresses. Simulated lobe pump studies have shown that high shear stress in these processing steps is sufficient to cause minor changes to protein structure.…”

Section: Implications In Physiology and Bioprocessingmentioning

confidence: 99%

The effects of shear flow on protein structure and function

Bekard

Asimakis

Bertolini³

et al. 2011

Biopolymers

181

140

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Toxoplasma gondii usually causes an asymptomatic and then latent infection in human adults; however, a potentially fatal disseminated form can occur in immunocompromised patients. Given that the diagnosis of acute Toxoplasma infection, as opposed to latent disease, relies on finding direct evidence of T. gondii infection in tissue, pathologic examination is critical. There have only been a few reports describing the cytomorphology of Toxoplasma in exfoliative cytology, and no reports of the findings in Thin Prep. In this report, we describe a fatal case of toxoplasmosis in a cardiac transplant patient that was diagnosed by respiratory cytopathology. Although the extracellular organisms were well visualized on the Wright‐Giemsa stained cytospin, they were only faintly seen on the Pap‐stained cytospin trapped within mucin and were not easily appreciated on the ThinPrep slides nor the H&E stained cell block sections. An immunohistochemical stain for Toxoplasma performed on the cell block was strongly positive, and an autopsy performed on the patient confirmed disseminated infection. Our case illustrates that the diagnosis of Toxoplasma in exfoliative cytology specimens can be challenging since organisms are not well visualized on ThinPrep or Pap‐stained material; therefore, Wright‐Giemsa stained material can be particularly helpful. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.

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Section: Implications In Physiology and Bioprocessingmentioning

confidence: 99%

The effects of shear flow on protein structure and function

Bekard

Asimakis

Bertolini³

et al. 2011

Biopolymers

181

140

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“…In the case of a Rushton turbine the jet flow slowly changes direction from a circumferential direction to a more radial direction with increasing radial distance from the axis 4,17,18 . Thin shear layer theory can be applied and an approximate self-similar solution can be obtained for the jet (see Yoon et al 15 ).…”

Section: Decomposition Of Mean Flowmentioning

confidence: 99%

Reynolds number scaling of flow in a Rushton turbine stirred tank. Part I—Mean flow, circular jet and tip vortex scaling

Yoon

Hill

Balachandar

et al. 2005

Chemical Engineering Science

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“…The earliest attempts at numerical simulations of flow field in mechanically agitated vessels employed an approach called impeller boundary condition approach (Harvey and Greaves, 1982;Middleton et al, 1986;Pericleous and Patel, 1987;Ranade et al, 1989;Ranade and Joshi, 1990;Kresta and Woods, 1991;Fokema et al, 1994;Armenante et al, 1994). In this approach, impeller was not physically modeled and was represented either in terms of boundary conditions at the surface of the volume swept by it or in terms of source terms distributed throughout its volume.…”

Section: Cfd Modeling Of Mechanically Agitated Baffled Tanksmentioning

confidence: 99%

CFD modeling of pilot-scale pump-mixer: Single-phase head and power characteristics

Singh

Mahajani

Shenoy

et al. 2007

Chemical Engineering Science

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The present work involves single-phase computational fluid dynamics (CFD) simulations of continuous flow pump-mixer employing topshrouded Rushton turbines with trapezoidal blades. Baffle-impeller interaction has been modeled using sliding mesh and multiple reference frame approaches. Standard k-model has been used for turbulence modeling. Several CFD runs representing different combinations of geometric and process parameters have been carried out. Results of CFD simulations have been used to find out two macroscopic performance parameters of pump-mixer-power consumption and head generated by the impeller. The simulation results have been compared with the experimental data obtained on a pilot-scale setup. Good agreement between CFD predictions and experimental results is observed. In most cases, sliding mesh approach is found to perform better than multiple reference frame approach. Details from CFD simulations have been used to have an insight into the pumping action of the impeller.

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Prediction of the three‐dimensional turbulent flow in stirred tanks

Abstract: Efforts to model the turbulent flow in stirred tanks Kolar's (1982)

Cited by 155 publications

References 31 publications

The effects of shear flow on protein structure and function

The effects of shear flow on protein structure and function

Reynolds number scaling of flow in a Rushton turbine stirred tank. Part I—Mean flow, circular jet and tip vortex scaling

CFD modeling of pilot-scale pump-mixer: Single-phase head and power characteristics

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