Tribology problems generally, and particularly high-temperature tribology (HTT), is a critical and complex topic based on the interaction between several intrinsic and extrinsic parameters. This involved complex phenomena, resulting in synergistic effects between mechanical, physical, chemical, and thermal solicitations. Introducing artificial intelligence tools, coupled with the design of the experiment, is an original approach to implement a successful transition from traditional "experimental guidance" to "experimental guidance associated with a data-driven" approach. The current study delves into the utilization of machine learning (ML) with simulation to help in the choice of the parameters for experimentation, and the development of predictive models. A detailed framework that takes into account the coupling between such tools is presented. Different scenarios are discussed to data drive the collaborative schema between the design of experiment, numerical development, and ML algorithms. This approach gives several opportunities such as the identification of the well-impacted parameters, optimization of the experimental design, and the proposition of predictive models. With the suitable proposed model, time loss, production costs, precision results, and man-hours could be saved or improved.