Prediction of Tumor-Infiltrating CD20+ B-Cells in Patients with Pancreatic Ductal Adenocarcinoma Using a Multilayer Perceptron Network Classifier Based on Non-contrast MRI

Li, Qi; Yu, Jieyu; Zhang, Hao; Meng, Yinghao; Liu, Yan Fang; Jiang, Hui; Zhu, Mengmeng; Li, Na; Zhou, Jian; Liu, Fang; Fang, Xu; Li, Jing; Feng, Xinxin; Lu, Jianping; Shao, Chengwei; Bian, Yun

doi:10.1016/j.acra.2021.11.013

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Although CD20+ B cells in TLSs are related to positive patient prognosis, their function in the TME is not straightforward ( 51 ). B cells usually exhibit antitumor-related effects such as antigen presentation and antibody production in humans.…”

Section: Pancreatic Cancer and Tilsmentioning

confidence: 99%

Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

et al. 2023

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Pancreatic cancer (PC) is extremely malignant and shows limited response to available immunotherapies due to the hypoxic and immunosuppressive nature of its tumor microenvironment (TME). The aggregation of immune cells (B cells, T cells, dendritic cells, etc.), which is induced in various chronic inflammatory settings such as infection, inflammation, and tumors, is known as the tertiary lymphoid structure (TLS). Several studies have shown that TLSs can be found in both intra- and peritumor tissues of PC. The role of TLSs in peritumor tissues in tumors remains unclear, though intratumoral TLSs are known to play an active role in a variety of tumors, including PC. The formation of intratumoral TLSs in PC is associated with a good prognosis. In addition, TLSs can be used as an indicator to assess the effectiveness of treatment. Targeted induction of TLS formation may become a new avenue of immunotherapy for PC. This review summarizes the formation, characteristics, relevant clinical outcomes, and clinical applications of TLSs in the pancreatic TME. We aim to provide new ideas for future immunotherapy of PC.

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Section: Pancreatic Cancer and Tilsmentioning

confidence: 99%

Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

et al. 2023

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“…All studies which investigated the role of imaging methods in TILs levels prediction in PDAC cases focused on the use of radiomics and artificial intelligence (AI) to analyze the radiomics [ 106 – 110 ] and the majority of them suggested the usage of radiomics models combined with non-radiomics features obtained from imaging studies.…”

Section: Other Cancersmentioning

confidence: 99%

“…Another interesting machine learning model was proposed by Li et al via non-contrast MRI in 156 PDAC patients. The authors focused on CD20 + B Cells level reflection in radiological images created through radiomics development [ 110 ].…”

Section: Other Cancersmentioning

confidence: 99%

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Tumor infiltrating lymphocytes and radiological picture of the tumor

et al. 2023

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Tumor microenvironment (TME) is a complex entity that includes besides the tumor cells also a whole range of immune cells. Among various populations of immune cells infiltrating the tumor, tumor infiltrating lymphocytes (TILs) are a population of lymphocytes characterized by high reactivity against the tumor component. As, TILs play a key role in mediating responses to several types of therapy and significantly improve patient outcomes in some cancer types including for instance breast cancer and lung cancer, their assessment has become a good predictive tool in the evaluation of potential treatment efficacy. Currently, the evaluation of the density of TILs infiltration is performed by histopathological. However, recent studies have shed light on potential utility of several imaging methods, including ultrasonography, magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT), and radiomics, in the assessment of TILs levels. The greatest attention concerning the utility of radiology methods is directed to breast and lung cancers, nevertheless imaging methods of TILs are constantly being developed also for other malignancies. Here, we focus on reviewing the radiological methods used to assess the level of TILs in different cancer types and on the extraction of the most favorable radiological features assessed by each method.

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MR-based follow-up after brachytherapy and proton beam therapy in uveal melanoma

et al. 2023

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Purpose MRI is increasingly used in the diagnosis and therapy planning of uveal melanoma (UM). In this prospective cohort study, we assessed the radiological characteristics, in terms of anatomical and functional imaging, of UM after ruthenium-106 plaque brachytherapy or proton beam therapy (PBT) and compared them to conventional ultrasound. Methods Twenty-six UM patients were evaluated before and 3, 6 and 12 months after brachytherapy (n = 13) or PBT (n = 13). Tumour prominences were compared between ultrasound and MRI. On diffusion-weighted imaging, the apparent diffusion value (ADC), and on perfusion-weighted imaging (PWI), the time-intensity curves (TIC), relative peak intensity and outflow percentages were determined. Values were compared between treatments and with baseline. Results Pre-treatment prominences were comparable between MRI and ultrasound (mean absolute difference 0.51 mm, p = 0.46), but larger differences were observed post-treatment (e.g. 3 months: 0.9 mm (p = 0.02)). Pre-treatment PWI metrics were comparable between treatment groups. After treatment, brachytherapy patients showed favourable changes on PWI (e.g. 67% outflow reduction at 3 months, p < 0.01). After PBT, significant perfusion changes were observed at a later timepoint (e.g. 38% outflow reduction at 6 months, p = 0.01). No consistent ADC changes were observed after either treatment, e.g. a 0.11 × 10−3mm2/s increase 12 months after treatment (p = 0.15). Conclusion MR-based follow-up is valuable for PBT-treated patients as favourable perfusion changes, including a reduction in outflow, can be detected before a reduction in size is apparent on ultrasound. For brachytherapy, a follow-up MRI is of less value as already 3 months post-treatment a significant size reduction can be measured on ultrasound.

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Prediction of Tumor-Infiltrating CD20+ B-Cells in Patients with Pancreatic Ductal Adenocarcinoma Using a Multilayer Perceptron Network Classifier Based on Non-contrast MRI

Cited by 6 publications

References 32 publications

Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

Tumor infiltrating lymphocytes and radiological picture of the tumor

MR-based follow-up after brachytherapy and proton beam therapy in uveal melanoma

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