Centrifugal pumps are susceptible to various faults, particularly under challenging conditions such as high pressure. Swift and accurate fault diagnosis is crucial for enhancing the reliability and safety of mechanical equipment. However, monitoring data under fault conditions in centrifugal pumps are limited. This study employed an experimental approach to gather original monitoring data (vibration signal data) across various fault types. We introduce a multi–scale sensing Convolutional Neural Network (MS–1D–CNN) model for diagnosing faults in centrifugal pumps. The network structure is further optimized by examining the impact of various hyperparameters on its performance. Subsequently, the model’s efficacy in diagnosing centrifugal pump faults has been comprehensively validated using experimental data. The results demonstrate that, under both single and multiple operating conditions, the model not only reduces reliance on manual intervention but also improves the accuracy of fault diagnosis.