Responding to the location of a target is slower when it appears at a recent distractor location [ignored-repetition (IR) trial] than when it arises at a new position [control (CO) trial], defining the location negative priming (NP) effect. On IR trials, both the distractor location and response are from the prior trial, and the locus question asks whether the delayed responding that arises is caused by the reused distractor position (i.e., a location locus) or the need to execute a distractor output (i.e., a response locus). A location NP procedure was used, incorporating a many:1 location-to-response mapping design, along with a response cue on some trials. A response locus for the location NP effect was indicated. Distractor-turned-target responses took longer to initiate than new outputs (many:1 paradigm), and valid response cues reduced distractor response interference and the location NP effect. Importantly, a possible S-R compatibility problem within the many:1 S-R paradigm was not supported.