Prediction the clinical EPR effect of nanoparticles in patient-derived xenograft models

Jeon, Sangmin; Jun, Eunsung; Chang, Hyeyoun; Yhee, Ji Young; Eun-Young, Koh; Kim, Yeounhee; Jung, Jae Yun; Jeong, Eun Ji; Lee, Jong Won; Shim, Man Kyu; Yoon, Hong Yeol; Chang, Suhwan; Kim, Kwangmeyung; Kim, Song Cheol

doi:10.1016/j.jconrel.2022.09.007

Cited by 22 publications

(13 citation statements)

References 48 publications

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“…This is partly due to the decomposition of calcium carbonate and the generation of CO 2 bubbles under acid microenvironment, 1 and the efficient retention of the nanoparticles by the EPR effect. 36 , 37 The thermal images of tumor sites are shown in Figure 7C . The tumor temperature in 5% glucose group was slightly increased after 5 min of laser irradiation.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Nanoparticles Codelivering Doxorubicin and Amorphous Calcium Carbonate Preloaded with Indocyanine Green for Enhanced Chemo-Photothermal Cancer Therapy

Yu¹,

Wang²,

Xie³

et al. 2023

IJN

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Background Multifunctional stimuli-responsive nanoparticles with photothermal-chemotherapy provided a powerful tool for improving the accuracy and efficiency in the treatment of malignant tumors. Methods Herein, photosensitizer indocyanine green (ICG)-loaded amorphous calcium-carbonate (ICG@) nanoparticle was prepared by a gas diffusion reaction. Doxorubicin (DOX) and ICG@ were simultaneously encapsulated into poly(lactic-co-glycolic acid)-ss-chondroitin sulfate A (PSC) nanoparticles by a film hydration method. The obtained PSC/ICG@+DOX hybrid nanoparticles were characterized and evaluated by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), transmission electron microscopy (TEM), and differential scanning calorimetry (DSC). The cellular uptake and cytotoxicity of PSC/ICG@+DOX nanoparticles were analyzed by confocal laser scanning microscopy (CLSM) and MTT assay in 4T1 cells. In vivo antitumor activity of the nanoparticles was evaluated in 4T1-bearing Balb/c mice. Results PSC/ICG@+DOX nanoparticles were nearly spherical in shape by TEM observation, and the diameter was 407 nm determined by DLS. Owing to calcium carbonate and disulfide bond linked copolymer, PSC/ICG@+DOX nanoparticles exhibited pH and reduction-sensitive drug release. Further, PSC/ICG@+DOX nanoparticles showed an effective photothermal effect under near-infrared (NIR) laser irradiation, and improved cellular uptake and cytotoxicity in breast cancer 4T1 cells. Importantly, PSC/ICG@+DOX nanoparticles demonstrated the most effective suppression of tumor growth in orthotopic 4T1-bearing mice among the treatment groups. In contrast with single chemotherapy or photothermal therapy, chemo-photothermal treatment by PSC/ICG@+DOX nanoparticles synergistically inhibited the growth of 4T1 cells. Conclusion This study demonstrated that PSC/ICG@+DOX nanoparticles with active targeting and stimuli-sensitivity would be a promising strategy to enhance chemo-photothermal cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Multifunctional Nanoparticles Codelivering Doxorubicin and Amorphous Calcium Carbonate Preloaded with Indocyanine Green for Enhanced Chemo-Photothermal Cancer Therapy

Yu¹,

Wang²,

Xie³

et al. 2023

IJN

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“…Nanoparticle accumulation in tumors has been shown to correspond to functional blood vessel density, indicating that blood vessels must be perfused to effectively deliver nanoparticles (Bellary et al, 2020; Doi et al, 2016; Geretti et al, 2015; Jeon et al, 2022; Koukourakis et al, 1999; Ojha et al, 2017; Stapleton, Allen, et al, 2013; Sulheim et al, 2018). If a tumor is not well perfused or it has a low blood vessel density, the efficiency of nanoparticle delivery will be low, and the treatment may be ineffective.…”

Section: Factors Influencing Nanoparticle Extravasation and Retentionmentioning

confidence: 99%

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Cooley,

Wegierak,

Exner

2024

WIREs Nanomed Nanobiotechnol

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Nanomedicine in oncology has not had the success in clinical impact that was anticipated in the early stages of the field's development. Ideally, nanomedicines selectively accumulate in tumor tissue and reduce systemic side effects compared to traditional chemotherapeutics. However, this has been more successful in preclinical animal models than in humans. The causes of this failure to translate may be related to the intra‐ and inter‐patient heterogeneity of the tumor microenvironment. Predicting whether a patient will respond positively to treatment prior to its initiation, through evaluation of characteristics like nanoparticle extravasation and retention potential in the tumor, may be a way to improve nanomedicine success rate. While there are many potential strategies to accomplish this, prediction and patient stratification via noninvasive medical imaging may be the most efficient and specific strategy. There have been some preclinical and clinical advances in this area using MRI, CT, PET, and other modalities. An alternative approach that has not been studied as extensively is biomedical ultrasound, including techniques such as multiparametric contrast‐enhanced ultrasound (mpCEUS), doppler, elastography, and super‐resolution processing. Ultrasound is safe, inexpensive, noninvasive, and capable of imaging the entire tumor with high temporal and spatial resolution. In this work, we summarize the in vivo imaging tools that have been used to predict nanoparticle distribution and treatment efficacy in oncology. We emphasize ultrasound imaging and the recent developments in the field concerning CEUS. The successful implementation of an imaging strategy for prediction of nanoparticle accumulation in tumors could lead to increased clinical translation of nanomedicines, and subsequently, improved patient outcomes.This article is categorized under: Diagnostic Tools In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery Emerging Technologies

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“…374 As an alternative, PDX models can also be used to predict the heterogeneity and complexity of tumors for tumor stratification. 375 4.2.3. Artificial intelligence.…”

Section: Future Directionsmentioning

confidence: 99%

Nanoprobe-based molecular imaging for tumor stratification

Ma,

Mao,

et al. 2023

Chem. Soc. Rev.

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Prediction the clinical EPR effect of nanoparticles in patient-derived xenograft models

Cited by 22 publications

References 48 publications

Multifunctional Nanoparticles Codelivering Doxorubicin and Amorphous Calcium Carbonate Preloaded with Indocyanine Green for Enhanced Chemo-Photothermal Cancer Therapy

Multifunctional Nanoparticles Codelivering Doxorubicin and Amorphous Calcium Carbonate Preloaded with Indocyanine Green for Enhanced Chemo-Photothermal Cancer Therapy

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Nanoprobe-based molecular imaging for tumor stratification

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