Predictive ability of prognostic nutritional index in surgically resected gastrointestinal stromal tumors: a propensity score matching analysis

Shi, Weikun; Zhang, Xinhua; Zhang, Jian; Yu, Miao; Yuan, Yujie; Xiong, Wei; Zhang, Changhua; Wei, Zhe-Wei

doi:10.1093/jjco/hyz078

Cited by 17 publications

(32 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, LMR seemed to be irrelevant to the RFS of GIST patients, which is different from previous studies 14 . In addition, the PNI, a nutritional score based on albumin levels and lymphocytes, was also related to RFS of GIST patients before PSM and after PSM in present study 11,12 (Figure S1 ).…”

Section: Discussionsupporting

confidence: 53%

“…Currently, some GIST-specific parameters based on postoperative pathologies, such as tumor size, primary tumor location, mitotic index, and tumor rupture, have been used to stratify the risk of recurrence for GISTs 2,[5][6][7] . Meanwhile, the recent effort has shed light on the role of preoperative cancer-related inflammation and nutrition status in cancer progression, such as gastric cancer 8 , colorectal cancer 9 , non-small lung cancer 10 , and gastrointestinal stromal tumor [11][12][13][14][15][16] . Several preoperative immuno-inflammatory-based prognostic scores, such as the preoperative neutrophil to lymphocyte ratio (NLR), the lymphocyte to monocyte ratio (LMR), and the platelet to lymphocyte ratio (PLR), reflect the systematic inflammatory response, with some evidence revealing that they are prognostic for GISTs [13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Combined Index of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Predict Recurrence After Radical Resection in Gastrointestinal Stromal Tumors: a propensity scores matching analysis

Zhao

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP) can reflect systemic inflammation and nutritional status simultaneously, with some evidence revealing its prognostic value for some tumors. However, the effect of HALP on recurrence-free survival (RFS) in patients of gastrointestinal stromal tumors (GISTs) has not been reported. Therefore, the present study aimed to investigate the prognostic value of HALP in GIST patients. Methods Data from 591 untreated patients who underwent R0 resection for primary and localized GISTs at West China Hospital between December 2008 and December 2016 were included. Clinicopathological data, preoperative albumin, blood routine information, postoperative treatment, and recurrence status were recorded. To eliminate the baseline inequivalence, the propensity scores matching (PSM) method was introduced. The relationship between RFS and preoperative HALP was investigated. Results The optimal cutoff value for the HALP was determined by the x-Tile analysis at 31.5. HALP was significantly associated with tumor site, tumor size, mitosis, Ki67, NIH risk category and adjuvant therapy (all P<0.001). Before PSM, GIST patients with an increased HALP had a significantly poor RFS (P < 0.001), and low HALP was an independent risk factor for poor RFS (HR=0.0551, 95% CI: 0.313 - 0.968, P=0.038). In NIH high-risk GIST patients, GIST patients with low HALP had a worse RFS than patients with high HALP (P<0.05). After PSM, 188 pairs of GIST patients were identified, GIST patients with an increased HALP still had a significantly poor RFS after PSM (P<0.001), and low HALP was still an independent risk factor for poor RFS (HR=0.585, 95% CI: 0.316 - 0.972, P=0.042). Conclusions HALP had a statistically significant correlation with postoperative pathology and postoperative treatment. Furthermore, HALP has a strong ability to predict the RFS in GIST patients with radical resection.

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Combined Index of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Predict Recurrence After Radical Resection in Gastrointestinal Stromal Tumors: a propensity scores matching analysis

Zhao

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The medians and ranges of the PLR, NLR, and PNI were 107.107 (19.770–566.842), 2.143 (0.076–37.496), and 47.646 (26.155–65.155), respectively. We chose the medians of the PLR, NLR, and PNI as the cutoff points to divide the patients into low and high groups, according to a previous study ( 17 ).…”

Section: Resultsmentioning

confidence: 99%

“…The PNI, composed of albumin and lymphocytes, was initially used to evaluate the immunological and nutritional aspects of patients undergoing gastrointestinal tract surgery ( 29 ). Numerous previous studies have shown that low PNI was associated with poorer progression-free survival and overall survival in patients with malignant tumors, including high recurrence risk for GISTs ( 17 , 30 , 32 , 33 ). In this study, the results indicated that GIST patients with a low PNI had shorter RFS than those with a high PNI.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Novel Prognostic Nomogram for Recurrence-Free Survival of Patients With Primary Gastrointestinal Stromal Tumors After Surgical Resection: Combination of Prognostic Nutritional Index and Basic Variables

Chen

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

BackgroundGastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumors in the digestive tract, often recrudescing even after R0 resection. Adjuvant tyrosine kinase inhibitor therapy prolonged recurrence-free survival (RFS). This study aimed to develop a novel nomogram for predicting the RFS of patients following surgical resection of GISTs.MethodsClinicopathologic data of patients with GISTs at Tianjin Medical University General Hospital (Tianjin, China) from January 2000 to October 2019 were retrospectively reviewed. Univariate and multivariate Cox regression analyses were used to select the suitable variables from the training cohort to construct a nomogram for 2- and 5-year RFS. The 1,000 bootstrap samples and calibration curves were used to validate the discrimination of the nomogram. The receiver operating characteristic analysis(ROC) was used to compare the predictive ability of the nomogram and present four commonly used risk stratification systems: National Institutes of Health (NIH)–Fletcher staging system; NIH–Miettinen criteria; Modified NIH criteria; and Air Forces Institute of Pathology risk criteria (AFIP).ResultsUnivariate and multivariate analyses showed that the tumor site, tumor size, mitotic index, tumor rupture, and prognostic nutritional index were significant factors associated with RFS. These variables were selected to create the nomogram for 2- and 5-year RFS (all P<0.05). The 2- and 5-year the ROC of the nomogram were 0.821 (95% confidence interval [CI]: 0.740–0.903) and 0.798 (95% CI: 0.739–0.903); NIH–Fletcher criteria were 0.757 (95% CI: 0.667–0.846) and 0.683 (95% CI: 0.613–0.753); NIH–Miettinen criteria were 0.762 (95% CI: 0.678–0.845) and 0.718 (95% CI: 0.653–0.783); Modified NIH criteria were 0.750 (95% CI: 0.661–0.838) and 0.689 (95% CI: 0.619–0.760); and AFIP were 0.777 (95% CI: 0.685–0.869) and 0.708 (95% CI: 0.636–0.780). Hence, the predictive probabilities of our nomogram are better than those of other GIST risk stratification systems.ConclusionThis nomogram, combining tumor site, tumor size, mitotic index, tumor rupture, and prognostic nutritional index, may assist physicians in providing individualized treatment and surveillance protocols for patients with GISTs following surgical resection.

show abstract

Prognostic Nutritional Index is a valuable preoperative prognostic biomarker in Mexican patients surgically intervened on gastrointestinal stromal tumors: a retrospective cohort study

Herrera-Goepfert,

Soca-Chafre,

Oñate-Ocaña

et al. 2024

Support Care Cancer

View full text Add to dashboard Cite

Predictive ability of prognostic nutritional index in surgically resected gastrointestinal stromal tumors: a propensity score matching analysis

Abstract: Prognostic nutritional index was found to be correlated with prognosis in GISTs before and after propensity score matching and its incorporation improved the prognostic stratification of NIH risk criteria.

Cited by 17 publications

References 38 publications

Combined Index of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Predict Recurrence After Radical Resection in Gastrointestinal Stromal Tumors: a propensity scores matching analysis

Combined Index of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Predict Recurrence After Radical Resection in Gastrointestinal Stromal Tumors: a propensity scores matching analysis

Novel Prognostic Nomogram for Recurrence-Free Survival of Patients With Primary Gastrointestinal Stromal Tumors After Surgical Resection: Combination of Prognostic Nutritional Index and Basic Variables

Prognostic Nutritional Index is a valuable preoperative prognostic biomarker in Mexican patients surgically intervened on gastrointestinal stromal tumors: a retrospective cohort study

Contact Info

Product

Resources

About