Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects

Rus, Alma; López-Sánchez, José Alberto; Martínez-Martos, José Manuel; Ramírez-Expósito, María Jesús; Molina, Francisco; Correa-Rodríguez, María; Aguilar-Ferrándiz, María Encarnación

doi:10.1007/s40291-023-00677-8

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Cited by 5 publications

References 60 publications

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Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agents

Silva,

Pacheco-Barrios,

Fregni

2024

Exp Brain Res

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Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agents

Silva,

Pacheco-Barrios,

Fregni

2024

Exp Brain Res

View full text Add to dashboard Cite

Effect of menopause on circulating amino acid concentrations in women with fibromyalgia and healthy women

Rus,

Coca-Guzmán,

Molina

et al. 2025

Maturitas

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Microbially Produced Bile Acids are Associated with High Levels of IgG Autoantibodies and Worse Mental Well-being in Fibromyalgia Subjects

Jakobsson,

Carlsson,

Erngren

et al. 2024

Preprint

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Fibromyalgia (FM) is a disease primarily associated with chronic widespread pain, but other common symptoms are anxiety and depression. We previously proposed that autoimmunity contributes to FM based on findings of increased immunoglobulin G binding to satellite glial cells (anti-SGC IgG) in FM subjects compared to healthy controls (HC). Emerging research suggests that an altered gut microbiota composition is connected to psychological symptoms in FM rather than pain. Gut microbiota can produce or alter bile acids (BAs) and short-chain fatty acids (SCFAs), which have immune and inflammatory functions. Here, we investigate alterations in BA and SCFA concentrations in FM subjects compared to healthy controls (HC) and potential associations with FM symptoms and anti-SGC IgG levels. Bile acids and SCFAs were quantified using liquid chromatography coupled with high-resolution mass spectrometry and anti-SGC IgG levels were assessed with immunocytochemistry. The correlations between FM symptoms, anti-SGC IgG levels, and serum concentrations of 24 BAs and 11 SCFAs in 35 FM subjects and 32 matched HC were examined. Fibromyalgia subjects had significantly higher levels of microbially produced BAs than HC. Strikingly, 11 out of 24 BAs were significantly elevated in FM subjects with high, compared to those with low, anti-SGC IgG levels. Concentrations of specific BAs were associated with increased disease severity and worse mental well-being. These results revealed increased levels of secondary BAs in FM subjects compared to HC. The strong association between BAs, anti-SGC IgG levels, and mental well-being may help elucidate the importance of BAs in the psychological symptoms of FM.

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Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects

Cited by 5 publications

References 60 publications

Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agents

Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agents

Effect of menopause on circulating amino acid concentrations in women with fibromyalgia and healthy women

Microbially Produced Bile Acids are Associated with High Levels of IgG Autoantibodies and Worse Mental Well-being in Fibromyalgia Subjects

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