Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Lök, Uğur; Gülaçtı, Umut; Ekmekçi, Burcu; Bulut, Taner; Çelik, Murat

doi:10.17712/nsj.2017.2.20160330

Cited by 12 publications

(14 citation statements)

References 34 publications

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“…In a retrospective study by Lok et al (27), who investigated AIS patients, MPV was found to have no predictive or prognostic value. This study also showed similar findings in CV patients, and it was concluded that MPV had no value regarding the differential diagnosis between CV and PV.…”

Section: Discussionmentioning

confidence: 95%

Importance of complete blood count parameters and neutrophil-to-lymphocyte ratio in central and peripheral vertigo

Bilge¹

2020

GMJ

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Section: Discussionmentioning

confidence: 95%

Importance of complete blood count parameters and neutrophil-to-lymphocyte ratio in central and peripheral vertigo

Bilge¹

2020

GMJ

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“…Another study by Nataios et al (16) measured MPV values within the first 24 hours after the onset of stroke and found that MPV levels were not associated with stroke severity and limitation of neurological functions. Further, a retrospective study by Lok et al (17) in 2017 which 798 first time acute ischemic stroke patients participated, showed that MPV values were not associated with short-term stroke prognosis and neurological functions. Also, a study compared MPV values of 281 first-episode acute ischemic stroke and 164 first-episode hemorrhagic stroke patients and found that MPV values were high in both groups but it is not associated with the prognosis (5).…”

Section: Discussionmentioning

confidence: 96%

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

Demir¹

2019

BMB

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Stroke is a rapid onset of focal or global loss of cerebral function and is the most common cause of mortality and morbidity in adulthood cancer and heart disease patients. Although it has been reported that mean platelet volume (MPV) values may be an independent risk factor for the severity and prognosis of stroke, the results of previous studies are inconsistent. The aim of the present study was to determine the MPV values of ischemic stroke patients which reflects the activity and function of platelets and to observe its effect on clinical outcomes. Method: Sixty-two acute ischemic stroke patients were recruited for the study. Clinical information, MPV, platelet, white blood cell (WBC) and neutrophil, CRP and troponin-T levels were obtained. Results: The mean ± standard deviation age was 72.4±12.6 years. At the end of the study, 28 patients were discharged and 34 patients passed away. The frequency of bilateral stroke was higher in deceased patients (p=0.005). In addition, platelet counts were significantly higher in discharged patients (p=0.016). At first admission, MPV values were 10.59±1.01 fL in discharged patients and 11.29±1.12 fL in deceased patients (p=0.029). At the end of the study, MPV values were measured as 11.46±1.28 fL in deceased patient sand 10.47±0.74 fL in discharged patients (p<0.001). WBC and neutrophil counts, troponin-T and CRP values were not significantly different between deceased and discharged patients (p>0.05). Conclusion: Our study indicated that MPV and platelet levels may be associated with mortality in acute ischemic stroke patients and can be used as prognostic markers.

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“…Hypertension was the most prevalent risk factor in this study with a percentage of 82. Study conducted by Lok U et al 13 and A. Muscari et al showed hypertension to be the most prevalent risk factor with a percentage of 74 and 84.7 respectively. The other common risk factors were smoking, alcohol, diabetes mellitus and dyslipidaemia.…”

Section: Risk Factors For Strokementioning

confidence: 94%

A Prospective Study of Role of Mean Platelet Volume, Platelet Distribution Width as Prognostic Markers in Acute Ischemic Stroke Patients

Narasimhamurthy¹,

Ramesh²,

Chaitanya³

2019

jebmh

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BACKGROUND Stroke is a global health problem. Platelet activation & aggregation are critical in pathogenesis of acute ischemic stroke. The mean platelet volume (MPV) and platelet distribution width (PDW) are laboratory markers associated with platelet function and activity. Increased values in thromboembolic disease is reflected as an important risk factor. We wanted to assess the severity of acute ischemic stroke according to modified Rankin scale and determine the value of mean platelet volume and platelet distribution width. We also wanted to establish the correlation between mean platelet volume, platelet distribution width with the severity of acute ischemic stroke and correlate the value of mean platelet volume, platelet distribution width with other risk factors for stroke. METHODS A prospective study was undertaken among patients admitted in ESIC Medical College & PGIMSR from January 2017 to June 2018. Study comprised of around 150 cases of acute ischemic stroke without previous thrombotic events. Severity of ischemic stroke was assessed by the Modified Rankin Scale. Patients were divided into 2 groups based on Rankin score (Group 1: Score 0-2, and Group 2: Score 3 or more). Blood samples were taken to measure MPV and PDW. RESULTS MPV and PDW were significantly elevated in patients who suffered a severe stroke defined as modified Rankin score of 3 to 6. Patients with higher MPV had worse outcome at the end of one week. After controlling for the risk profile associated with ischemic stroke in the multivariate logistic regression model, the effect of MPV in ischemic stroke remained statistically significant. CONCLUSIONS MPV and PDW can be considered as laboratory markers for the risk of acute ischemic stroke. The MPV is associated with ischemic stroke severity and has a high value for discriminating severe from mild ischemic stroke.

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Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Cited by 12 publications

References 34 publications

Importance of complete blood count parameters and neutrophil-to-lymphocyte ratio in central and peripheral vertigo

Importance of complete blood count parameters and neutrophil-to-lymphocyte ratio in central and peripheral vertigo

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

A Prospective Study of Role of Mean Platelet Volume, Platelet Distribution Width as Prognostic Markers in Acute Ischemic Stroke Patients

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