Predictive and Prognostic Significance of Vascular Endothelial Growth Factor (VEGF) and Response to VAD Protocol of Chemotherapy In Multiple Myeloma Patients

Abstract

other bad prognostic factors such as stage, high B2 macroglobulin level in multiple myeloma patients ,and when multi analysis was applied a high significant association were observed reflecting an independent risk of vascular endothelial growth factor, or its soluble receptor-2, ten myeloma patients (17.8%) showed complete response, while twenty seven (48.2%) patients showed either very good or partial response and rest patient showed no response with tolerated toxicity according to WHO criteria of toxicity and the median time to progression for responders was 22.5 months while 95% confidence interval (CI) was 1.71-3.09. CONCLUSION: Vascular endothelial growth factor and its soluble receptor -2 had a prognostic and predictive utility in responded multiple myeloma patient indicating that the rate of angiogenesis was decreased after successful treatment and might open a future direction for target therapy