This study identified college students’ weight gain and body image during COVID-19. A descriptive cross-sectional study was carried out, with data collection occurring from January to May 2023, using an electronic form distributed via social networks or email. Students (+18 years) participated in the study and answered a semi-structured questionnaire, containing questions related to sociodemographic aspects, clinical aspects, and the silhouette scale. A comparison of several events and clinical conditions was made between the period before and during COVID-19. In total, 52 responses were given (86.3% female; 41.3% Black people). In total, 60% were diagnosed with obesity, and 20% were diagnosed with Diabetes Mellitus. Pain related to muscular and joint structures (34.3%) and anxiety (60%) were reported to have been concerns before COVID-19. During COVID-19, this scenario was maintained, in addition to symptoms related to fatigue/tiredness (52.3%) and body weight gain (61.4%). The existence of an active social life (54.3%) and the regular practice of physical activity (65.2%) were reported as occurring only before COVID-19.