Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis

Holmes, Laurens; Rios, Jasmine; Berice, Betyna N.; Benson, Jacqueline A.; Bafford, Nastocia; Parson, Kadedrah; Halloran, Daniel

doi:10.3390/medicines8010001

Cited by 13 publications

(17 citation statements)

References 60 publications

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“…Helicobacter pylori is a gram-negative, curved, and microaerophilic bacillus which are infecting almost 50% of the population. The infection can occur at any time in life but when it occurs in early childhood, a permanent infection is established ( 1 , 2 ). The bacterium is considered a pathogen of global interest that causes gastritis, peptic ulcer, and lymphomas associated with lymphoid mucosa tissue which are associated with gastric carcinoma ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Effect of a Proteolytic Enzyme From the Fruits of Solanum granuloso-leprosum (Dunal) Against Helicobacter pylori

et al. 2021

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Helicobacter pylori is a gram-negative, helix-shaped, and microaerophilic bacteria that colonizes the human gastric mucosa, causing chronic infections, gastritis, peptic ulcer, lymphomas associated with lymphoid mucosa tissue, and gastric cancer. H. pylori is considered a Type 1 human carcinogen by WHO. The prevalence of the infection is estimated in more than half of the world population. Treatment of H. pylori infection includes antibiotics and proton pump inhibitors, but the increasing antibiotic resistance promotes the research of novel, more effective, and natural antibacterial compounds. The aim of this work was to study the effect of the partially purified proteolytic extract (RAP) of the fruits from Solanum granuloso-leprosum (Dunal), a South American native plant, and a purified fraction named granulosain I, against H. pylori, to obtain natural food additives for the production of anti-H. pylori functional foods. Furthermore, granulosain I and RAP could be used as natural adjuncts to conventional therapies. Granulosain I and RAP antibacterial activity was evaluated as minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against H. pylori NCTC 11638 (reference strain) and twelve H. pylori wild strains, using a microdilution plating technique (Clinical and Laboratory Standards Institute). All the strains tested were susceptible to granulosain I with MIC from 156.25 to 312.5 μg/mL and MBC from 312.5 to 625 μg/mL, respectively. Besides, all the strains tested were susceptible to the RAP with MIC from 312.5 to 625 μg/mL and MBC from 625 to 1,250 μg/mL, respectively. The effect of granulosain I and RAP on the transcription of H. pylori genes encoding pathogenic factors, omp18, ureA, and flaA, with respect to a housekeeping gene (16S rRNA), was evaluated by RT-PCR technique. The band intensity between pathogenic factors and control gene was correlated under treated or untreated conditions, using the ImageJ program. Granulosain I and RAP significantly decreased the expression of pathogenic factors: omp18, ureA, and flaA. The combined inhibitory effect of granulosain I or RAP and an antibiotic such as, amoxicillin (AML, 10 μg), clarithromycin (CLA, 15 μg), levofloxacin (LEV, 5 μg), and metronidazole (MTZ, 5 μg) was evaluated, using the agar diffusion technique. Granulosain I and RAP showed significant synergistic effect on AML, CLA, and LEV, but no significant effect on MTZ was observed. Besides, granulosain I and RAP did not show toxicological effects at the concentrations studied. Finally, granulosain I and RAP could be used as safe natural food additives and as adjuvants for conventional therapies against H. pylori.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Effect of a Proteolytic Enzyme From the Fruits of Solanum granuloso-leprosum (Dunal) Against Helicobacter pylori

et al. 2021

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“…(5) individuals' characteristics (the mean age and sex); ( 6) the sample size (control and intervention groups); ( 7) the type of cranberry prescribed; (8) the dosage of cranberry; (9) the duration of intervention; (10) the type of intervention in comparison groups; (11) participant health conditions; (12) the outcome assessment method throughout the trial for the intervention and control groups and ( 13) the main outcome.…”

Section: Data Extractionmentioning

confidence: 99%

“…Generally, H. pylori infection increases the risk of malignancy and the expense of H. pylori-associated morbidity (7,8) . Eradication of H. pylori infection has been proven to reduce the incidence of gastric cancer (9,10) .…”

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confidence: 99%

The effect of cranberry supplementation on Helicobacter pylori eradication in H. pylori positive subjects: a systematic review and meta-analysis of randomised controlled trials

et al. 2021

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Helicobacter pylori infection is one of the most common chronic bacterial infections. Cranberry has been suggested for Helicobacter pylori eradication. We aimed to conduct the first meta-analysis to summarize current evidence on effects of cranberry supplementation on Helicobacter pylori eradication in H. pylori positive subjects. We searched the online databases up to December 2020. Four randomized clinical trials (RCTs) were included with human subjects, investigating the effect of cranberry on Helicobacter pylori eradication. The pooled results were expressed as the odds ratio with 95% confidence intervals. Based on 5 effect sizes with a total sample size of 1935 individuals, we found that according to the odds ratio, there was a positive effect of cranberry supplementation on Helicobacter pylori eradication, increasing the chance of Helicobacter pylori eradication by 1.27 times, but this relationship was not statistically significant (overall OR: 1.27; 95% CI: 0.63, 2.58). The results also indicated the moderate between-study heterogeneity (I2=63.40%; P=0.03) of the studies. However, there were no significant differences in some subgroup analyses in the duration of treatment, the duration of follow up and the Jadad score. Our findings revealed that although cranberry had a positive effect on Helicobacter pylori eradication in adults, this effect was not statistically significant. Due to the small number of included studies and moderate heterogeneities, the potential of cranberry supplementation on Helicobacter pylori eradication should be validated in large, multicenter, and well-designed RCTs in the future.

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“…CagA helps to invade the epithelial cells, and VacA induces apoptosis of the cells by activation of pro-apoptotic factor Bcl-2 associated X protein (Bax) [ 8 ]. After invasion of the epithelial cells, tumor cell proliferation occurs through inhibition of the activity of tumor suppressor gene, p53, thereby preventing apoptosis [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Coinfection of Helicobacter pylori and Hepatitis C Virus in the Development of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

et al. 2021

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Background The relationship between Helicobacter pylori ( H. pylori ) and hepatocellular carcinoma (HCC) was firstly proposed in 1994 after Ward et al demonstrated the role of Helicobacter hepaticus in the development of HCC in mice. Studies also investigated the role of hepatitis B virus (HBV) and hepatitis C virus (HCV) coexisting with H. pylori in causing HCC. A causal relationship was never confirmed, and the relationship remains controversial. This meta-analysis aimed to summarize the research on this topic and investigate if a relationship exists between H. pylori infection and the development of HCC and if the presence of HCV and HBV along with H. pylori plays a role in liver carcinogenesis. Methods Following PRISMA guidelines, we performed a systematic review of all relevant studies published in the literature using the keywords “ Helicobacter pylori ” and “hepatocellular carcinoma” on major literature databases, including PubMed, EMBASE, Web of Science, and Cochrane controlled trials register. A total of 656 research studies were identified between 1994 and 2020. Of those, 26 qualified under our selection criteria. Patients who were positive for HCC were classified as cases and those who did not have HCC were classified as controls. The H. pylori status and HCV status, if available, were identified for both groups. Statistical analysis was carried out by a biostatistician according to the Cochrane reviewer’s handbook. Results Out of the 26 studies included in the final analysis, 13 were retrospective case-control studies, 11 were cross-sectional studies, and two were prospective case-control and cohort studies. Overall, the prevalence of H. pylori infection was 64.78% (561 of 866) amongst HCC cases and 47.92% (1,718 of 3,585) in the non-HCC control group. The summary odds ratio (OR) for the association of H. pylori infection with the risk for HCC (using the random-effects model, which accounted for the heterogeneity across the 26 studies) was determined to be 4.75 (95% confidence interval (CI): 3.06 - 7.37, I 2 = 63%). We also performed a subgroup analysis to determine the odds of developing HCC in the presence of H. pylori and HCV coinfection. The summary OR of it was 12.76 (95% CI: 4.13 - 39.41, I 2 = 78%). The summary OR for the risk of developing HCC in the presence of HCV infection without H. pylori infection was 2.21 (95% CI: 0.70 - 6.94, I 2 = 79%). Whereas, the odds of developing HCC in the presence of only H. pylori infection without HCV was found to be 0.54 (95% CI: 0.11 - 2.63, I ...

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Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis

Cited by 13 publications

References 60 publications

Antimicrobial Effect of a Proteolytic Enzyme From the Fruits of Solanum granuloso-leprosum (Dunal) Against Helicobacter pylori

Antimicrobial Effect of a Proteolytic Enzyme From the Fruits of Solanum granuloso-leprosum (Dunal) Against Helicobacter pylori

The effect of cranberry supplementation on Helicobacter pylori eradication in H. pylori positive subjects: a systematic review and meta-analysis of randomised controlled trials

Coinfection of Helicobacter pylori and Hepatitis C Virus in the Development of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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