Predictive Effect of Triglyceride‑Glucose Index on Clinical Events In Patients With Type 2 Diabetes Mellitus and Acute Myocardial Infarction: Results From an Observational Cohort Study In China

Abstract

Background: Triglyceride glucose (TyG) index is considered a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular outcomes. However, the prognostic value of TyG index in patients with type 2 diabetes mellitus (T2DM) and acute myocardial infarction (AMI) remains unclear. Methods: A total of 1932 consecutive patients with T2DM and AMI were enrolled in this study. Patients were divided into tertiles according to their TyG index levels. The incidences of major adverse cardiac and cerebral events (MACCEs), including all-cause death, non-fatal MI, non-fatal stroke, cardiac rehospitalization and revascularization, were recorded. The TyG index was calculated as the ln [fasting triglycerides (mg/dL) ×fasting plasma glucose (mg/dL)/2].Results: Kaplan-Meier curves showed that the incidences of cardiac rehospitalization (p=0.001), revascularization (p<0.001) and composite MACCEs (p=0.027) increased with TyG index tertiles. Multivariable Cox regression models revealed that the TyG index was positively associated with all-cause death, cardiovascular death, cardiac rehospitalization, revascularization and composite MACCEs. The addition of TyG index to a baseline risk model had an incremental effect on the predictive value for composite MACCEs [AUC: 0.663 vs. 0.708, p<0.001].Conclusions: The TyG index was significantly associated with MACCEs, suggesting that the TyG index may be a valid marker for risk stratification and prognosis in patients with T2DM and AMI.Trial registration: retrospectively registered

High triglyceride-glucose index in young adulthood is associated with incident cardiovascular disease and mortality in later life: insight from the CARDIA study

“…Recently, the triglyceride-glucose (TyG) index, measured by the fasting plasma glucose and triglyceride, has been proposed as a reliable surrogate marker of IR and shown to highly correlate with IR [5,6]. Growing evidence has been demonstrated that the TyG index is related to adverse cardiovascular outcomes in the general population [7][8][9], as well as among certain high-risk patients, such as diabetes [10], hypertension [11], myocardial infarction [12], acute coronary syndrome [13], and after percutaneous coronary intervention [14]. In addition, several studies also report a predictive role of the TyG index with adverse cardiovascular outcomes among the general population [7,15] and patients with cardiovascular diseases [12,13].…”

“…Growing evidence has been demonstrated that the TyG index is related to adverse cardiovascular outcomes in the general population [7][8][9], as well as among certain high-risk patients, such as diabetes [10], hypertension [11], myocardial infarction [12], acute coronary syndrome [13], and after percutaneous coronary intervention [14]. In addition, several studies also report a predictive role of the TyG index with adverse cardiovascular outcomes among the general population [7,15] and patients with cardiovascular diseases [12,13]. However, most of the prior studies mainly focused on older adults with CVD events and mortality, and were inherently limited by short follow-up periods and the use of measured TyG index at a single time point.…”

Triglyceride Glucose Index for Predicting Major Adverse Cardiovascular Events in Chinese Patients with Hypertension

“…Previous studies have indicated that the TyG index can predict the occurrence of adverse cardiovascular events in patients with diabetes. [20][21][22] In addition, the TyG index can predict MACE in patients with non-ST-elevation MI. Based on our study, this easy method for identifying IR may optimize the risk stratification of hypertensive patients with a high cardiovascular risk.…”

“…18,19 Additionally, other studies have indicated that the TyG index can predict the occurrence of adverse cardiovascular events in patients with diabetes. [20][21][22] Moreover, the TyG index can predict MACE in patients with non-ST segment elevation acute coronary syndrome. 23 However, no studies have focused on the relationship between the TyG index and MACE in patients with HTN.…”

Comparison of the Diagnostic Value Between Triglyceride-Glucose Index and Triglyceride-to-High Density Lipoprotein Cholesterol Ratio in MAFLD Patients: A Retrospective Cross-Sectional Study

“…Being used to detect IR, TyG seems to be cheaper and more convenient than the homeostasis model assessment of insulin resistance (HOMA-IR) index (14). TyG is also associated with cardiometabolic diseasesand is a risk prognostic factor for stroke, diabetes mellitus, acute myocardial infarction and acute coronary syndrome (15)(16)(17). Besides, TyG may be a useful indicator of MAFLD not only in adults but also in children and the elderly(18-20).…”