Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy

Luk, Yiu Shiobhon; Shum, John Sing Fai; Sze, Henry C.K.; Chan, Lucy; Ng, Wai‐Tong; Lee, Anne W.M.

doi:10.1016/j.oraloncology.2012.07.011

Cited by 39 publications

(52 citation statements)

References 31 publications

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“…This emerging subgroup of young, long‐term head and neck cancer survivors has a lifetime risk for developing delayed radiation‐associated lower cranial neuropathies, particularly because the latency of lower cranial neuropathies in patients treated for any head and neck cancer has been reported to range from 1 to 34 years . However, current research regarding radiation‐associated lower cranial neuropathies is primarily focused on patients treated for nasopharyngeal cancer, likely because of the therapeutic dose of RT required in the proximity of the skull base and peripheral nerve tracts . Research regarding radiation‐associated lower cranial neuropathies in oropharyngeal cancer is limited.…”

Section: Discussionmentioning

confidence: 99%

Late radiation‐associated dysphagia with lower cranial neuropathy in long‐term oropharyngeal cancer survivors: Video case reports

Hutcheson¹,

Yuk

Holsinger

et al. 2015

Head & Neck

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Section: Discussionmentioning

confidence: 99%

Late radiation‐associated dysphagia with lower cranial neuropathy in long‐term oropharyngeal cancer survivors: Video case reports

Hutcheson¹,

Yuk

Holsinger

et al. 2015

Head & Neck

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“…First is the development of genomic instability in cancer cells. Evidence of defective DNA repair has been found in OED 164. Immunoexpression of human MutL protein homolog 1 (hMLH1), a protein of the mismatch repair system, was shown to be decreased in lesions with lower degrees of dysplasia compared to lesions with more severe dysplasia 165.…”

Section: Introductionmentioning

confidence: 99%

Can Immunohistochemistry Serve as an Alternative to Subjective Histopathological Diagnosis of Oral Epithelial Dysplasia?

AbdulMajeed

Farah

2013

Biomark�Cancer

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Many attempts have been made to identify objective molecular biomarkers to diagnose and prognosticate oral epithelial dysplasia (OED) because histopathological interpretation is subjective and lacks sensitivity. The majority of these efforts describe changes in gene expression at protein level in OED as determined by immunohistochemistry (IHC). However, the literature on these putative markers of oral cancer progression is vast and varied. The main purpose of this article is to review current knowledge on biomarkers of protein expression for OED by IHC approaches. We further discuss these findings in terms of the proposed essential hallmarks of cancer cells to better understand their role in oral oncogenesis.

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“…Luk et al (3) also found CNP at diagnosis to be a prognostic factor. In our cohort, 82% of the patients received systemic therapy and none of the included patients presented with CNP prior to treatment initiation.…”

Section: Discussionmentioning

confidence: 94%

“…Radiation-induced cranial nerve palsy (RICNP) is a severe long-term effect observed in patients treated with high-dose radiation therapy (RT) for nasopharyngeal carcinoma, with an incidence ranging between 3.7 and 30.9% in the literature (1)(2)(3)(4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported that the lower cranial nerves (CNs) are more susceptible to radiation damage (1)(2)(3). RICNP significantly compromises the quality of life: Damage of the glossopharyngeal nerve (IX) causes loss of sensation in the pharynx and decreased salivation; palsy of the vagus nerve (X) leads to impaired parasympathetic functions of almost all organs; and palsy of the hypoglossal nerve (XII) causes complete paralysis of the ipsilateral side of the tongue.…”

Section: Introductionmentioning

confidence: 99%

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Radiation-induced lower cranial nerve palsy in patients with head and neck carcinoma

Glanzmann

Yousefi

Loewenich

et al. 2015

Molecular and Clinical Oncology

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Abstract. Radiation-induced cranial nerve palsy (RICNP) is a severe long-term complication in patients with head and neck cancer following high-dose radiation therapy (RT). We present the case report of a patient with bilateral RICNP of the hypoglossal and vagus cranial nerves (XII/X) following postoperative RT in the era prior to the introduction of intensity-modulated RT (IMRT), and an analysis of our IMRT patient cohort at risk including the case of a XII RICNP. A total of 201 patients whose glosso-pharyngeal (IX), X and XII cranial nerves had been exposed to >65 Gy definitive IMRT in our institution between January, 2002 and December, 2012 with or without systemic therapy, were retrospectively identified. A total of 151 patients out of 201 fulfilling the following criteria were included in the analysis: Locoregionally controlled disease, with a follow-up (FU) of >24 months and >65 Gy exposure of the nerves of interest. So far, one of the assessed 151 IMRT patients at risk exhibited symptoms of RICNP after 6 years. The mean/median FU of the entire cohort was 71/68 months (range, 27-145). The results were compared with literature reports. In conclusion, RICNP appears to be a rare complication. However, a longer FU and a larger sample size are required to draw reliable conclusions on the incidence of RICNP in the era of IMRT.

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Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy

Cited by 39 publications

References 31 publications

Late radiation‐associated dysphagia with lower cranial neuropathy in long‐term oropharyngeal cancer survivors: Video case reports

Late radiation‐associated dysphagia with lower cranial neuropathy in long‐term oropharyngeal cancer survivors: Video case reports

Can Immunohistochemistry Serve as an Alternative to Subjective Histopathological Diagnosis of Oral Epithelial Dysplasia?

Radiation-induced lower cranial nerve palsy in patients with head and neck carcinoma

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