Predictive factors for airway hyperresponsiveness in children with respiratory symptoms

Yavuz, Süleyman Tolga; Civelek, Ersoy; Tuncer, Ayfer; Şahiner, Ümit Murat; Şekerel, Bülent Enis

doi:10.1016/j.anai.2011.01.020

Cited by 6 publications

(16 citation statements)

References 31 publications

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“…In contrast, in an earlier study including children who were also without an obstructive pattern, no significant relationship between personal allergy and the presence of AHR was detectable (7). However, unlike the earlier study, in the present study patients with predominantly exercise-induced symptoms were excluded.…”

Section: Association Of Allergy Atopic History and Eosinophilia Withcontrasting

confidence: 88%

“…In accordance with the results of previous studies, we identified an association between high eosinophilia counts and AHR (7,14,23). Unfortunately, our database of eosinophilia was incomplete, therefore it was not included in the multivariate analysis.…”

Section: Association Of Allergy Atopic History and Eosinophilia Withsupporting

confidence: 87%

“…Nocturnal cough is highly prevalent in adult patients with asthma (27) and a high frequency of nocturnal cough is shown to be significantly related to the presence of AHR (28). While our findings confirm the importance of wheezing and nocturnal cough as predictors of AHR, Yavuz et al (7) found that, in spite of a quite similar patient selection, there is neither a significant association of AHR with wheezing nor with nocturnal cough. They observed significance only for the co-existence of nocturnal and exercise-induced cough, a combination with reduced significance in our study.…”

Section: Association Of Asthma-like Symptoms With Ahrcontrasting

confidence: 67%

“…Several studies have reported a negative association between AHR and dyspnea which might be due to a worse perception of breathlessness (7,29). The prevalence of dyspnea was also more frequent in children without AHR, however without reaching significance.…”

Section: Association Of Asthma-like Symptoms With Ahrmentioning

confidence: 90%

“…Admission symptoms were investigated at the patient's first visit by a standardized list of questions based on the International Study of Asthma and Allergies in Childhood (ISAAC)(5) using the German questionnaire developed by Duhme et al (1998) (6). Additional questions were used as have been previously described in detail elsewhere (7).Wheezing not associated with colds was defined as a positive response to the question: "Has your child had wheezing or whistling in their chest in the past twelve months without a cold". Wheezing associated with colds had the same definition as the clinical evidence of a viral cold (8).…”

Section: Definitionsmentioning

confidence: 99%

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Novel predictors of airway hyperresponsiveness in children with respiratory symptoms without obstructive pattern

Reinsberg

Siebert

Dreher

et al. 2021

Preprint

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Background: Methacholine challenge (MCC) is the most common method to detect airway hyperresponsiveness (AHR). Although MCC is accepted as safe diagnostic tool, it is time consuming and could be exhausting for patients. Thus, it might be helpful to identify predictive factors for AHR. We aimed to develop a diagnostic tool for predicting AHR in children with respiratory symptoms without obstructive pattern. Methods: Data from children who had undergone MCC were analyzed retrospectively. The demographic features of patients along with laboratory results were collected. Results: A total of 123 children with a median age of 10.5 years were enrolled. AHR was detected in 81 children (65.8%). The age of the children with AHR was significantly younger. The prevalences of aeroallergen sensitization, nocturnal cough, wheezing and a baseline forced expiratory flow at 75% of vital capacity (FEF75) <65% were significantly more frequent in children with AHR. Multivariate logistic regression analysis revealed age, ever wheezing, nocturnal cough, tree pollen allergy and FEF75<65% as independent predictors of the AHR. A weighted clinical risk score was developed (range, 0-75 points). At a cutoff point of 35 the presence of AHR is predicted with a specificity of 90.5% and a positive predictive value (PPV) of 91.5%. Conclusion: In children suspected of having asthma, but without an obstructive pattern, combining independent predictors, which can be easily obtained in clinical practice, in a novel prediction rule might be used to identify children with AHR.

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Section: Association Of Allergy Atopic History and Eosinophilia Withcontrasting

confidence: 88%

Section: Association Of Allergy Atopic History and Eosinophilia Withsupporting

confidence: 87%