Predictive Factors for Craniopharyngioma Recurrence: A Systematic Review and Illustrative Case Report of a Rapid Recurrence

Prieto, Ruth; Pascual, José M.; Subhi-Issa, Issa; Jorquera, Manuela; Yus, Miguel; Martínez, Roberto

doi:10.1016/j.wneu.2012.07.033

Cited by 79 publications

(62 citation statements)

References 79 publications

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“…33 A review in 2013 found variable associations of recurrence with proliferation markers and TP53 expression. 41 These individual studies on recurrence have generally used univariate analyses on relatively low sample numbers of archival specimens limiting the generalizability of their findings and likely contributing to their lack of reproducibility or consistency when repeated.…”

Section: Molecular Biology Of Tumor Recurrencementioning

confidence: 99%

“…In the limited molecular studies to date, increased expression of proliferation markers and TP53 have been observed in malignantly transformed specimens as well as in some rapidly recurring tumors. 25,41 While TP53 expression appears to be rare in nontransformed ACP, its related family member TP63 is widely expressed, particularly the deltaNp63 isoform 11,14,37 translating the therapeutic Opportunities and Challenges Ahead…”

Section: Molecular Biology Of Tumor Recurrencementioning

confidence: 99%

“…More detailed reviews of the histopathology of ACP, specific pathways, and the lessons learnt from mouse models may be found elsewhere. 30,35,36,41 Opportunities for Practice ACP is a clinically heterogeneous disease. At presentation, tumors may be variably solid to cystic and variably invasive and destructive of neighboring structures.…”

mentioning

confidence: 99%

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Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice

Apps¹,

Martinez-Barbera²

2016

FOC

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Since the first identification of CTNNB1 mutations in adamantinomatous craniopharyngioma (ACP), much has been learned about the molecular pathways and processes that are disrupted in ACP pathogenesis. To date this understanding has not translated into tangible patient benefit. The recent development of novel techniques and a range of preclinical models now provides an opportunity to begin to support treatment decisions and develop new therapeutics based on molecular pathology. In this review the authors summarize many of the key findings and pathways implicated in ACP pathogenesis and discuss the challenges that need to be tackled to translate these basic science findings for the benefit of patients.

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Section: Molecular Biology Of Tumor Recurrencementioning

confidence: 99%

Section: Molecular Biology Of Tumor Recurrencementioning

confidence: 99%

See 1 more Smart Citation

Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice

Apps¹,

Martinez-Barbera²

2016

FOC

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“…24 The only noticeable difference was a more extensively developed network of capillary vessels within the peritumoral gliosis in the sample taken from recurrent tumor (Fig. 1).…”

mentioning

confidence: 94%

“…Tumor recurrence represents one of the most challenging, unsettling issues regarding CPs owing to their unpredictability and the hazardous, demanding surgical treatment required. 24 For this reason, we first congratulate Bao et al for their excellent results-a high percentage of radical removal concurrent with remarkable low morbidity and mortality rates. Apart from their results, we wish to highlight the importance of their analysis, as they found that, among the potential factors that influence patient outcome following repeated surgery for CPs, tumor topography is a major variable that predicts both the postoperative status and the hypothalamic functional outcome.…”

mentioning

confidence: 99%