Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study

Nouri‐Mahdavi, Kouros; Hoffman, Douglas; Coleman, Anne L.; Liu, Gang; Li, Gang; Gaasterland, Douglas E.; Caprioli, Joseph

doi:10.1016/j.ophtha.2004.02.017

Cited by 654 publications

(473 citation statements)

References 39 publications

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“…In this case, this large effect was applicable to the entire distribution of data ( Figure 4) and this is noteworthy. This finding supports the results from other studies that have reported the same effect [23][24][25] and refutes the finding in at least one other study (albeit in patients with untreated normal tension glaucoma only) that there is no association between age and rate of VF progression. 26 The distribution of rate of MD loss also varied by baseline MD as indicated in the difference of the tails of the distribution rather than in the measures of central tendency in Figure 4.…”

Section: Discussionsupporting

confidence: 91%

Are rates of vision loss in patients in English glaucoma clinics slowing down over time? Trends from a decade of data

Boodhna

Saunders

Crabb

2015

Eye

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Purpose To examine changes in rates of visual field (VF) progression in patients attending a sample of glaucoma clinics in England between 1999 and 2012. Methods An archive of 473 252 Humphrey VFs recorded across the UK was retrospectively examined. Distribution of rates recorded in the first half of the decade was compared with the second. The relationship between age and severity of MD loss at baseline with rates of loss and frequency of testing was examined. Results VF series from 18 926 eyes were analysed. Median rate of MD loss for the period before and after 2003 was − 0.11 and − 0.06 dB/year, respectively, but the proportion of eyes with medium or fast rates of MD loss remained constant. Median rate of MD loss in older (470 years) eyes was faster than that observed in younger (o60 years) eyes (−0.21 compared with − 0.01 dB/ year). Median rate of loss did not vary with severity of MD loss at baseline. Frequency of testing, typically carried out annually, did not vary by age, rate of loss or disease severity. Conclusions VFs of eyes treated in the first half of the decade deteriorated more rapidly than those in the second half. Several factors might explain these differences but average effects were small and there was no reduction in the proportion of rapidly progressing eyes over the decade. Older age and, to a lesser extent, worse VF damage at diagnosis are indicators for faster VF loss in clinics, but frequency of VF testing was similar for all patients.

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Section: Discussionsupporting

confidence: 91%

Are rates of vision loss in patients in English glaucoma clinics slowing down over time? Trends from a decade of data

Boodhna

Saunders

Crabb

2015

Eye

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“…42,43 Both increasing age and greater IOP fluctuation increase the odds of VF progression by 30% (for each 5-year increment in age and 1-mm Hg increase in IOP fluctuation). 44 These findings could not be confirmed in the EMGT study, 45 and this discrepancy may be explained in the analysis not including postprogression IOP measurements.…”

Section: Commentmentioning

confidence: 99%

Glaucoma: an area of darkness

Hitchings

2008

Eye

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This review of Primary Open Angle Glaucoma looks at the management of the condition today. It does this by looking at the following areas: (a) the size of the problem; (b) the position of IOP, with respect to its elevation and fluctuation; (c) optic nerve head changes; and (d) visual function changes. In doing so, it contrasts what is known now with ideas and concepts that were prevalent at the time of the two previous Bowman lecturers, Duke Elder and Drance, as well as noting concepts about the disease that were current at the time of William Bowman. The review concludes by suggesting challenges in this area that lie ahead.

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“…Studies have indicated that reduction of IOP can prevent the onset of glaucomatous disc damage 1 or slow the rate of further damage once it has occurred. 2 IOP can be lowered in three ways:…”

Section: Glaucoma Management In Pregnancy: a Questionnaire Surveymentioning

confidence: 99%

Glaucoma management in pregnancy: a questionnaire survey

Vaideanu¹,

Fraser²

2005

Eye

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Background The management of glaucoma in a pregnant woman can pose a challenge for the ophthalmologist. The risks and benefits to the mother and foetus must be weighed. When it is decided that treatment is necessary, there is no consensus as to the safest treatment. This study was designed to garner the experiences and views of UK ophthalmologists with regard to this scenario. Methods All consultant ophthalmologists in the UK were sent a questionnaire. They were asked if they had previous experience treating pregnant women with glaucoma, what management they had used, what management they would currently employ, and, if they were to use medical treatment, what would their first choice agent be. Results A total of 282 out of 605 questionnaires were returned. Of the respondents, 26% had previously treated pregnant women with glaucoma. Most (71%) had continued with the therapy that the women were already on. In all, 34% had observed the situation and had not needed to treat. When asked what they would currently do in this scenario, 31% were unsure. A total of 40% would simply continue the prepregnancy treatment. A total of 45% of respondents, if they were to use medical treatment, would use beta-blockers, compared to 33% who would use prostaglandins. Conclusion Although it is thought to be a relatively rare clinical situation, over a quarter of our respondents had first hand experience of the management of glaucoma in pregnancy. Our results indicate some uncertainty about the optimal strategy. It is unlikely that trials will be performed and we suggest guidelines be produced using current knowledge and modified as evidence appears.

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Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study

Cited by 654 publications

References 39 publications

Are rates of vision loss in patients in English glaucoma clinics slowing down over time? Trends from a decade of data

Are rates of vision loss in patients in English glaucoma clinics slowing down over time? Trends from a decade of data

Glaucoma: an area of darkness

Glaucoma management in pregnancy: a questionnaire survey

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