Predictive factors for malignancy in intraductal papillary-mucinous tumors of the pancreas

Sugiyama, Masanori; Suzuki, Yutaka; Izumisato, Yumi; Abe, Nobutsugu; Tomita, Masaki; Mori, Toshiyuki

doi:10.1016/s0016-5085(03)82222-9

Cited by 40 publications

(82 citation statements)

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“…[7][8][9][10] Therefore, the recommended management of main duct IPMNs is surgical resection according to the international consensus guideline for the management of IPMNs. 2 IPMNs tend to show a longitudinal wide spreading into the pancreatic duct.…”

Section: Discussionmentioning

confidence: 99%

“…6 The rate of the malignancy of the branch duct IPMNs is low, whereas main duct IPMNs are frequently malignant. [7][8][9] The average frequency of malignancy in main duct IPMNs based on several reports is 70%. 10 Therefore, the current treatment recommendation is that all main duct IPMNs should be considered candidates for resection.…”

Section: Ipmns Have Been Defined and Classified By The World Healthmentioning

confidence: 99%

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Surgical Strategy for Main Pancreatic Duct-Type Intraductal Papillary Mucinous Neoplasm of the Pancreas

Kuroki¹,

Adachi²,

Ono³

et al. 2012

HGE

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Section: Discussionmentioning

confidence: 99%

Section: Ipmns Have Been Defined and Classified By The World Healthmentioning

confidence: 99%

Surgical Strategy for Main Pancreatic Duct-Type Intraductal Papillary Mucinous Neoplasm of the Pancreas

Kuroki¹,

Adachi²,

Ono³

et al. 2012

HGE

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“…Vari studi dimostrano infatti come nelle IPMN dei dotti principali la progressione verso forme maligne, in situ o invasive, avvenga in una percentuale variabile dal 60% al 92%, con una media del 70%. Sulla base di tali dati, qualora le indagini preoperatorie pongano il sospetto di una IPMN del dotto principale o di tipo misto, l' exeresi chirurgica è di regola indicata [10,11,[14][15][16][17][18][19][20].…”

Section: Figura 1 Immagini Rm/tc Della Lesione Cistica Mucinosa Intrunclassified

“…Decisamente meno frequente è la cancerizzazione delle lesioni interessanti i dotti periferici, riscontrata in una percentuale variabile dal 6% al 46%, con una media del 25% [10,11,[14][15][16][17][18][19]. È da notare, però, come i due studi che descrivono la più alta frequenza di cancro invasivo (30% e 31% rispettiSulla base del referto della TC la paziente è stata sottoposta a colangio-RM (Figura 1).…”

Section: Figura 1 Immagini Rm/tc Della Lesione Cistica Mucinosa Intrunclassified

“…In considerazione della bassa frequenza di cancerizzazione, in particolar modo nelle lesioni di piccole dimensioni, l'intervento chirurgico può essere considerato in maniera più selettiva nei casi di IPMN dei dotti periferici. A tale riguardo, le linee guida internazionali [12] raccomandano l'intervento chirurgico nelle forme sintomatiche o in presenza di segni diretti o indiretti di cancerizzazione in atto [17,19,20].…”

Section: Conclusioniunclassified

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Main-duct intraductal papillary mucinous neoplasm of the pancreas: a case report

Manetti

Faini

Bucciero

et al. 2012

CMI

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INTRODUZIONELe neoplasie mucinose cistiche del pancreas possono essere classificate in due gruppi ben distinti: neoplasie papillari mucinose intraduttali (IPMN) e neoplasie mucinose cistiche (MCN) (Tabella I).Queste ultime sono maligne o potenzialmente tali anche se con una crescita molto lenta rispetto alle IPMN [2]. Spesso interessano donne di mezza età e la sintomatologia di esordio consiste principalmente in dolore addominale e presenza di una massa palpabile in epigastrio. Sono solitamente localizzate nella coda del pancreas e sono costituite da cisti mucinose uniloculari o multiloculari ben circoscritte con dimensioni medie di 7-10 cm [3,4] Caso clinico AbstractThree distinct entities among non-inflammatory cystic lesions of the pancreas have been defined: intraductal papillary mucinous neoplasm (IPMN), serous cystic neoplasm (SCN) and mucinous cystic neoplasm (MCN). IPMN is characterized by intraductal papillary growth and thick mucus secretion: its incidence has dramatically increased since its initial description. These lesions probably can progress towards invasive carcinoma. IPMNs are symptomatic in most cases: the typical presentation is a recurrent acute pancreatitis, without evident cause, of low or moderate severity. The diagnosis is usually based upon the imaging (CT/cholangio-MRI) demonstrating a pancreatic cystic mass, involving a dilated main duct, eventually associated to some filling defects, or a normal Wirsung duct communicating with the cyst lesion. Surgical treatment is generally indicated for main duct IPMN and branch duct IPMN with suspected malignancy (tumour size ≥ 30 mm, mural nodules, dilated main pancreatic duct, or positive cytology) or prominent symptoms. Herein we present a case of IPMN of the main duct which occurred with abdominal and back pain associated with weight loss. After the diagnosis, she successfully underwent surgery and is now in a follow-up program.

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Treatment Strategy for Intraductal Papillary Mucinous Neoplasm of the Pancreas Based on Malignant Predictive Factors

Hirono¹

2009

Arch Surg

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Predictive factors for malignancy in intraductal papillary-mucinous tumors of the pancreas

Cited by 40 publications

References 0 publications

Surgical Strategy for Main Pancreatic Duct-Type Intraductal Papillary Mucinous Neoplasm of the Pancreas

Surgical Strategy for Main Pancreatic Duct-Type Intraductal Papillary Mucinous Neoplasm of the Pancreas

Main-duct intraductal papillary mucinous neoplasm of the pancreas: a case report

Treatment Strategy for Intraductal Papillary Mucinous Neoplasm of the Pancreas Based on Malignant Predictive Factors

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