Predictive Factors for Platelet Count Variation After Splenectomy in Non-Traumatic Diseases

Abstract

Background: The spleen plays a central role in a range of diseases. As such, great emphasis has been placed on the procedure of spleen removal, the benefits and the numerous associated complications. Given the immediate risk of the thrombotic complications, the aim of this study was to evaluate clinical and laboratory patient characteristics in non-traumatic diseases of the spleen, and to investigate possible predictive factors for platelet count variation following the procedure. Methods: A total of 72 patients who underwent splenectomy were included in this retrospective study. Correlation coefficients as well as multiple linear regressions were used to assess the relationship between post-splenectomy platelet count and various preoperative clinical and laboratory patient characteristics. Results: Following multiple linear regression analysis, we determined that 54.93% of post-splenectomy platelet count variation was explained by admission platelet count (p = 0.00), lymphocyte count (p = 0.04), WBC count (p = 0.00), LOS (p = 0.00), patient gender (p = 0.00), spleen accessibility on admission (p = 0.02) and PT (p = 0.00). Conclusions: Platelet count variation following splenectomy for non-traumatic diseases can be predicted by assessing preoperative patient characteristics. The implications of this study suggest that by means of a prediction model, patient care could benefit from assessing and addressing various preoperative factors that lead to these complications.

Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study

“…Based on our results, the DPS and SPDP groups presented similar patterns of hematological changes after DP. Platelet counts of both the DPS and SPDP groups were elevated and peaked at POW2, which is consistent with previous studies [ 17 , 18 ]. Almost all peripheral blood cell populations were significantly higher in the DPS group than in the SPDP group.…”

Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study

“…Based on our results, the DPS and SPDP groups presented similar patterns of hematological changes after DP. Platelet counts of both the DPS and SPDP groups were elevated and peaked at POW2, which is consistent with previous studies [17,18]. Almost all peripheral blood cell populations were signi cantly higher in the DPS group than in the SPDP group.…”

Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study

“…Platelet counts of both the DPS and SPDP groups were elevated and peaked at POW2, which is consistent with previous studies [17,18]. Almost all peripheral blood cell populations were signi cantly higher in the DPS group than in the SPDP group.…”