Predictive Factors for Recurrence of Papillary Thyroid Carcinoma in Children and Adolescents

Gui, Yan; Huang, Dongmei; Hou, Yun; Wei, Xudong; Zhang, Jinming; Wang, Junyi

doi:10.3389/fonc.2022.833775

Cited by 8 publications

(18 citation statements)

References 29 publications

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“…PTC in children and adolescents is less common, but the recurrence rate is high (16.7-31.6%) ( 30 – 32 ). The results of our study showed that 40 patients (22.3%) had a recurrence, which was similar to Rubinstein’s study ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Thyroid Autoantibodies and Recurrence of Papillary Thyroid Carcinoma in Children and Adolescents

et al. 2022

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BackgroundNumerous studies reported connection between papillary thyroid carcinoma (PTC) and thyroid autoantibody in adults, but few of them have investigated whether there is a similar link in children and adolescents. The purpose of this research was to explore the relationship between clinicopathological features, prognosis and preoperative thyroid peroxidase antibody (TPOAb) as well as thyroglobulin antibody (TgAb) status in children and adolescents with PTC.MethodsThis study retrospectively reviewed 179 patients of PTC who underwent a thyroidectomy from January 2000 to June 2021 at Tianjin Medical University Cancer Hospital. We compared preoperative TgAb and TPOAb status with the clinicopathological features and prognosis of children and adolescents with PTC in different age groups.ResultsPatients with positive preoperative TPOAb and TgAb had lower recurrence rate in the younger group (P = 0.006, 0.047, respectively). Patients with positive TPOAb preoperatively had normal level of preoperative Tg and less cervical LNM than patients with negative TPOAb in children and adolescents (P < 0.05). Positive TPOAb preoperatively of PTC patients had a longer median DFS (113.4 months) than negative TPOAb (64.9 months) (P = 0.009, log-rank). Univariate analyses showed age, maximal tumor size, T stage, multifocality, lateral LNM and N staging were predictors for cancer recurrence in children and adolescents (P<0.05). Cox regression analysis found younger age (HR 0.224, P < 0.001), lateral LNM (HR 0.137, P = 0.010), N stage (HR 30.356, P < 0.001) were independent risk factors for recurrence.ConclusionsOur study found that presence of preoperative TPOAb and TgAb could serve as novel prognostic factors for predicting recurrence of PTC in children.

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Section: Discussionmentioning

confidence: 99%

Relationship Between Thyroid Autoantibodies and Recurrence of Papillary Thyroid Carcinoma in Children and Adolescents

et al. 2022

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“…A literature review of eighteen articles dealing with thyroid surgery in paediatric population is shown in Table 3 [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Most studies (18) included in our literature review were retrospective studies.…”

Section: Resultsmentioning

confidence: 99%

“…Study period varied from 1 year [ 17 ] to 18 years [ 22 ]. Studies with the most patients were those in which partial or total thyroidectomy was usually performed [ 12 , 13 , 15 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], while fewer patients were included in studies that analysed robotic trans-axillary and retro-auricular approach [ 14 ] or transoral endoscopic thyroidectomy via vestibular approach [ 17 ]. The most common complication in all operations was hypocalcaemia due to incidental parathyroidectomy and recurrent laryngeal nerve injury.…”

Section: Resultsmentioning

confidence: 99%

Thyroid Surgery in Children: A 5-Year Retrospective Study at a Single Paediatric Surgical Center and Systematic Review

Bukarica

Antić²,

Fratrić³

et al. 2022

Children

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The aim of this study was to analyse and evaluate our 5-year experience in paediatric thyroid surgery, as well as the specificities of this kind of surgery in the literature. This retrospective study was based on 19 operations in 17 patients aged from 5 to 17 years who were operated on due to thyroid pathology from 2017 until 2022. We presented data on surgical procedures and complications following surgery. Most of the patients were adolescent girls. The most common clinical presentations included enlarged thyroid gland, followed by thyroid nodules and hyperthyroidism. Eight total thyroidectomies, five left lobectomies, five right lobectomies, and three central neck dissections were performed. The most common histopathological diagnosis was hyperplastic diffuse colloid goitre, followed by papillary carcinoma, cystic nodule, follicular adenoma, Hashimoto thyroiditis and toxic adenoma. Postoperative course was uneventful, with four mild complications (one wound infection, one manifest hypocalcaemia, and two transitory recurrent laryngeal nerve paralysis). In our literature review, eighteen full-text articles were included and analysed. This study demonstrated that thyroid surgery in paediatric population is a safe and efficient procedure. Thyroid pathology in children significantly differs from that in the adults, and paediatric surgeons should be included into the team managing such cases.

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“…Виявлено, що МФ була незалежним чинником ризику для кількості метастазів у ЦЛВ і ЛЛВ [44], а дослідження D. Q. Ngo та співавт. [82] показало, що у дітей з ПРЩЗ МФ, максимальний діаметр пухлини, ЕТП і метастази у ЦЛВ були незалежними чинниками ризику метастазування у ЛЛВ.…”

Section: значення мультифокальностіunclassified

“…У дослідженні Y. Gui та співавт. [44] показано, що вогнища раку у віковій групі < 14 років були агресивнішими та переважно МФ порівняно з групою 14 -18 років. Дослідження S. Park [92] показало, що вікова група < 15 років мала агресивніші чинники, зокрема білатеральність і МФ.…”

Section: дитячий вікunclassified

Multifocal papillary thyroid cancer in children and adults. Lecture

Tovkai¹,

Palamarchuk²,

Hryshchenko³

et al. 2022

CE&ES

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Thyroid cancer is the 9th most common cancer in the world. Thus, in the year 2020, 586.000 cases of thyroid cancer were registered worldwide. The incidence rate among women is 10.1 per 100 thousand population, and among men — 3.1 per 100 thousand population. In Ukraine, in 2019, the standardized rate of incidence of thyroid cancer (world standard) was 6.9 per 100.000 population (2.8 among men, 10.5 among women). In the structure of the incidence of malignant neoplasms of the cervical spine, thyroid cancer ranks first place among women aged 18 — 29 (19.9 %), fourth among both men aged 18 — 29 (8.3 %, and women aged 30 — 54 (8.1 %). Over the past 40 years, increased incidence of thyroid cancer (in particular, papillary thyroid cancer) is observed in most countries, which can be explained by various factors, for example, overdiagnosis, a change in the prevalence of modified risk factors. In Ukraine, in the period from 1989 to 2012, the rate of incidence of papillary thyroid cancer among men increased by 115 %, among women — by 137 %, the annual increase in incidence of papillary thyroid cancer for men and women was 5 and 6 %, respectively. Multifocality in papillary thyroid cancer is a characteristic feature that is much more common in pediatric patients than in adults, but the number of studies in children is limited, which is associated with a lower prevalence of the disease in children. The results of investigations on the multifocality predictors and its role in influencing relapse, persistence, and survival in patients with papillary thyroid cancer are conflicting in both adults and pediatric population. Among the risk factors of multifocality, a smaller number of controversies concerns the links of metastasis in the lymphatic nodes, radiation in the anamnesis, childhood age, and for bilaterality — multifocality of the primary lobe and the presence of contralateral benign nodes (in adults). Other factors as predictors of multifocality have controversial significance and deserve attention in further research. The identification of reliable predictors of multifocality, especially with the help of preoperative data analysis, as well as multifocality risk stratification will facilitate the complex decision‑making process for the correct treatment tactics of children and adults with papillary thyroid cancer.

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Predictive Factors for Recurrence of Papillary Thyroid Carcinoma in Children and Adolescents

Cited by 8 publications

References 29 publications

Relationship Between Thyroid Autoantibodies and Recurrence of Papillary Thyroid Carcinoma in Children and Adolescents

Relationship Between Thyroid Autoantibodies and Recurrence of Papillary Thyroid Carcinoma in Children and Adolescents

Thyroid Surgery in Children: A 5-Year Retrospective Study at a Single Paediatric Surgical Center and Systematic Review

Multifocal papillary thyroid cancer in children and adults. Lecture

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