Predictive factors for secondary alveolar bone graft failure in patients with cleft alveolus

Abstract

Secondary alveolar bone grafting (SABG) is described as a method to achieve a complete alveolar ridge over the cleft in patients born with cleft lip and/or palate (CLP). 1 A bony bridge in the cleft area is a prerequisite for the eruption of the permanent lateral incisor or canine and enables orthodontic space closure or prosthetic rehabilitation in cases with cleft lateral agenesis. [2][3][4] The success rate for SABG with autologous bone is found to vary, usually ranging from 46% to 99%. [5][6][7][8] Several authors claim an association between the increased age at SABG and poor outcomes in terms of the decreased bone level, occurrence of complications, or need for re-surgery. 5,6,[9][10][11][12][13][14][15][16][17] In contrast, contradictory results have been presented, where no impact of age on SABG has been detected. 16,[18][19][20][21] in

The potential role of cfDNA-related innate immune responses in postoperative bone loss after alveolar bone grafting

“…Therefore, the local environment of the cleft is risky for enhancing bone loss. Oral hygiene, which can eliminate the local stimulus for periodontal inflammation, helps avoid bone grafting failure (16), which preliminarily supports our hypothesis that inhibition of local inflammation and innate immune responses could benefit bone grafting treatment.…”

“…However, even though the aforementioned factors have been taken care of, the improvement in surgical outcomes was not significant yet, and postoperative alveolar bone loss still exists. Recently, poor oral hygiene became another hotspot in the success of alveolar cleft reconstruction surgery, which was similar to periodontitis ( 3 , 16 , 42 ). Thus, a new aspect based on this concept could be the potential for solving this problem.…”