Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis

Loendersloot, L.L. van; Wely, Madelon van; Limpens, Jacqueline; Bossuyt, Patrick M.; Repping, Sjoerd; Veen, Fulco van der

doi:10.1093/humupd/dmq015

Cited by 279 publications

(246 citation statements)

References 71 publications

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“…This view is further supported by a recent meta-analysis that found that female age is the most important predictor of pregnancy in IVF in almost all the analyzed studies [27].…”

Section: Discussionmentioning

confidence: 55%

IVF results in patients with very low serum AMH are significantly affected by chronological age

Revelli

Biasoni

Gennarelli

et al. 2016

J Assist Reprod Genet

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Purpose The aims of this study were to assess the outcome of in vitro fertilization (IVF) in women with very low circulating anti-müllerian hormone (AMH) and to investigate factors affecting their probability of pregnancy. Methods The outcome of 448 IVF cycles in 361 women with circulating AMH <0.5 ng/ml was retrospectively analyzed. Results Cycle cancellation rate was 14.5 %; patients whose cycle was cancelled had significantly lower AMH than women who reached oocyte pickup (OPU). Among those who reached OPU, age significantly affected the success rate: despite comparable AMH levels, patients below 35 years obtained significantly more oocytes and a better clinical pregnancy rate (CPR)/OPU than patients aged 35-39 or 40-43 (31 % vs. 23.2 % vs. 10.2 %, respectively; p = 0.001). Differently, comparable IVF results were observed stratifying patients for AMH levels in the range 0.14-0.49 ng/ml. Multivariable logistic regression analysis confirmed that the probability of pregnancy was significantly affected by age, but not by small differences in AMH level. Conclusions Women with very low (<0.5 ng/ml) AMH levels undergoing IVF still have reasonable chances of achieving a pregnancy, but their prognosis is significantly affected by chronological age. Very low AMH levels are associated with a relevant risk of cycle cancellation but should not be considered a reason to exclude a couple from IVF.

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“…This view is further supported by a recent meta-analysis that found that female age is the most important predictor of pregnancy in IVF in almost all the analyzed studies [27].…”

Section: Discussionmentioning

confidence: 55%

IVF results in patients with very low serum AMH are significantly affected by chronological age

Revelli

Biasoni

Gennarelli

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Although the most desirable endpoint for transcriptomics studies is live birth, several studies examined the gene expression of CC in relation to embryo development (McKenzie et al 2004, Hasegawa et al 2005, Zhang et al 2005, Cillo et al 2007, Feuerstein et al 2007, Anderson et al 2009, Assou et al 2013. As embryos with the best morphological appearance are usually selected for uterine transfer and have been shown to implant at a higher rate than morphologically low-quality embryos (van Loendersloot et al 2010), the gene expression profiles of these studies may serve as an indirect marker of embryo viability and be at least loosely related to live birth rates.…”

Section: Microarray and Qrt-pcr Studies In Ivf Populations In Relatiomentioning

confidence: 99%

Granulosa cell biomarkers to predict pregnancy in ART: pieces to solve the puzzle

Kordus

LaVoie

2017

Reproduction

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Cumulus and mural granulosa cells of the ovarian follicle surround and interact with the developing oocyte. These follicular cells reflect the oocyte's overall health and may indicate subsequent developmental competence of embryos. Biomarkers of granulosa cells associated with individual oocytes could potentially be used in assisted reproduction to indicate which embryos have the best chance of implanting in the uterus and completing gestation. In this review, we have performed a comprehensive assessment of the recent literature for human cumulus and mural granulosa cell mRNA biomarkers as they relate to pregnancy and live birth. A critical discussion of variables affecting granulosa gene expression profiles for in vitro fertilization patients, including patient demographics and ovarian stimulation regimens, is presented. Although studies with microarray data were evaluated, this synopsis focuses on expressed genes that have been validated by quantitative RT-PCR. Furthermore, we summarize the current published data that support or refute identified granulosa expressed genes as potential biomarkers of embryos that give rise to ongoing pregnancy and live birth. Finally, we review studies that offer predictive models for embryo selection for uterine transfer based on biomarkers that show differential gene expression. Reproduction (2017) 153 R69-R83

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“…ARTs, and in particular in vitro fertilisation (IVF), have become a widely accepted form of reproduction since they emerged in the late 1970s [23]. It is estimated that over 5 million children have now been born worldwide as a result of ART treatments.…”

Section: Medical Virtue and Commerce In The 21 St Century: The Case Omentioning

confidence: 99%

On the fragility of medical virtue in a neoliberal context: the case of commercial conflicts of interest in reproductive medicine

et al. 2016

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Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis

Abstract: Female age, duration of subfertility, bFSH and number of oocytes, all reflecting ovarian function, are predictors of pregnancy after IVF. Better quality studies are necessary, especially studies that focus on embryo factors that are predictive of success in IVF.

Cited by 279 publications

References 71 publications

IVF results in patients with very low serum AMH are significantly affected by chronological age

IVF results in patients with very low serum AMH are significantly affected by chronological age

Granulosa cell biomarkers to predict pregnancy in ART: pieces to solve the puzzle

On the fragility of medical virtue in a neoliberal context: the case of commercial conflicts of interest in reproductive medicine

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