Predictive Factors of Antipsychotic Treatment Response in Patients with First Episode Schizophrenia

Abstract

Schizophrenia is an illness which is chronic that leads to disability. Particularly obtaining sufficient treatment response in patients with first episode schizophrenia is important in determining the course of the illness. Predicting treatment response with antipsychotic drugs would allow to obtain efficient clinical response by reducing unnecessary drug use and enhance the adherence to treatment. In this context, considering the importance of topic, this review is written out relevant to predictive factors of antipsychotic treatment response in patients with first episode schizophrenia. Electronic search was conducted for this review in Pubmed database. Although there are varied links between drug response and both biological, including pharmacological, neuroimaging and electroencephalography (EEG) findings, and clinical, including duration of untreated psychosis, antipsychotic agents which are used in treatment, soft neurological signs, kind and severity of psychotic symptoms and neurophysiologic indicator of frontal lobe function (NoGo Anteriorization, NGA), variables in studies which are conducted in this field, there is a need for further studies as a conclusion.