Predictive factors of coexisting cancer in Barrett’s high-grade dysplasia

Abstract

For patients with HGD, a lesion visible on endoscopy and/or HGD at multiple biopsy levels is associated with an increased risk for coexisting cancer. These patients should be considered for early esophagectomy.

Endoscopic diagnosis and therapies for Barrett esophagus: a review

“…Visible lesions in patients with dysplastic Barrett esophagus are associated with higher risk of invasive carcinoma (85,96) and should be treated with a tissueacquiring modality so these lesions can be appropriately resected and staged histologically (97).…”

Endoscopic Therapy of Neoplasia Related to Barrett's Esophagus and Endoscopic Palliation of Esophageal Cancer

“…Endoscopically visible lesions (Fig 1) associated with high-grade dysplasia have a higher risk for harboring cancer than fl at areas of dysplasia have. [16][17][18] Protruded, raised, or depressed lesions are at higher risk for submucosal invasion than fl at areas. Endoscopic resection (ER) provides an opportunity to accurately stage the depth of visible lesions in BE.…”

Barrett’s oesophagus

“…41,42 In a series of esophagectomies performed for presumed HGD identified by endoscopic biopsies, coexisting EA was found in 7 of 9 patients (78%) with a visible lesion and 7 of 22 patients (32%) without a visible lesion (P ϭ .02). 43 Risk of progression from HGD to EA is approximately 10% per year (range 6%-19%). Agreement: Aϩ 45%, A 40%, U 5%, D 6%, Dϩ 4%.…”