2015
DOI: 10.3892/mco.2015.499
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Predictive factors of cytotoxic damage in radioactive iodine treatment of differentiated thyroid cancer patients

Abstract: Radioactive iodine (I) therapy in patients suffering from differentiated thyroid cancer (DTC) is a targeted treatment commonly used for thyroid ablation and locoregional and distant metastatic spread management. Despite a significant proportion of the I dose entering the circulation, there is currently no detailed information regarding its effect on the blood cell system. In order to assess the cytotoxic effects ofI therapy on the circulatory system, blood cell levels, thyroid-related hormones and CD45 cell cy… Show more

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Cited by 10 publications
(8 citation statements)
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“…Monzen et al [18] evaluated the effect of RAI therapy on the hematopoietic system cell. The white blood cell count, the number of neutrophils and lymphocytes, platelet level, and hemoglobin were all significantly decreased by day 30 versus the first day after RAI therapy.…”
Section: Discussionmentioning
confidence: 99%
“…Monzen et al [18] evaluated the effect of RAI therapy on the hematopoietic system cell. The white blood cell count, the number of neutrophils and lymphocytes, platelet level, and hemoglobin were all significantly decreased by day 30 versus the first day after RAI therapy.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, PCT may be used as a biomarker for diagnosis, prognosis, and radiosensitivity in certain cancers. 35 Oncel et al certified that the PCT values of patients with metastatic lung cancer were higher than those of patients without metastasis. While comparing to healthy controls, the value of PCT was lower.…”
Section: Discussionmentioning
confidence: 99%
“…Neutrophil-to-lymphocyte ratio (NLR), one of the indicators of inflammation and immunology, is easily measured via peripheral blood sampling and is reportedly useful as a prognosis index of various types of cancer ( 12 , 13 , 14 , 15 ). Several studies have investigated the role of NLR in thyroid cancer, and reports evaluating changes in inflammatory markers and blood-cell count due to RAI treatment exist, but no reports of studies on the correlation between NLR and prognosis in patients with RAI-avid lung metastasis were found ( 16 , 17 ). This study aimed to determine the clinical prognostic factors, including NLR, in RAI-avid lung metastasis cases and to attempt risk classification to identify future cases for TKI therapy.…”
Section: Introductionmentioning
confidence: 99%