Predictive factors of depressive symptoms of elderly patients with cancer receiving first-line chemotherapy

Duc, Sophie; Rainfray, Muriel; Soubeyran, Pierre; Fonck, Marianne; Blanc, Jean‐Frédéric; Ceccaldi, J.; Cany, Laurent; Brouste, Véronique; Mathoulin‐Pélissier, Simone

doi:10.1002/pon.4090

Cited by 36 publications

(36 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…metastatic cancer [37][38][39][40]. In contrast to these studies, we did not find any statistically significant association between the medical, psychological, socio-environmental factors studied and the detection of a MDD or abnormal mood disorders screening.…”

Section: Studies Carried Out In Older Patients With Cancer Have Showncontrasting

confidence: 99%

Comparison of mood disorder screening scales in geriatric oncology: THYMOG study results

Boudin¹,

Laviec

Ghewy

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Early and systematic depression screening is recommended for older patients with cancer. The objective of this study is to evaluate the performance of three different mood disorder screening scales for detection of Major Depressive Disorder (MDD) in older patients with cancer. Methods: A prospective multicentric study was conducted in patients with cancer over 70 years of age, comparing three self-administered questionnaires: the 15-item Geriatric Depression Scale (GDS-15), the Hospital Anxiety and Depression Scale - Depression (HADS-D) and the Distress Thermometer (DT). Three weeks after initial assessment, in case of score above the standard cut-off, a reassessment of the patient’s mood was performed by the primary care physician, using the DSM-V MDD diagnostic criteria and the DT. Potential differences between an abnormal mood screening test and a confirmed MDD was assessed using variance analysis for each screening scale. Results: 93 patients with an average age of 81 years [70 - 95 years] were included. 66 patients had at least one abnormal score on one of the screening scales. A MDD was confirmed for 10 of the 36 reassessed patients (28%). Abnormal screening by the GDS-15 (p=0.021), the HADS-D (p=0.018) and the DT (p=0.045) was significantly associated with MDD diagnosis. Conclusions: The three screening scales enabled detection of MDD in older patients with cancer. Among the tested scales, the HADS-D could perform best in detecting MDD. However, these screening scales may not be sufficiently reliable for MDD screening in this population. Further studies are needed to confirm the results.

show abstract

Section: Studies Carried Out In Older Patients With Cancer Have Showncontrasting

confidence: 99%

Comparison of mood disorder screening scales in geriatric oncology: THYMOG study results

Boudin¹,

Laviec

Ghewy

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…When albumin decreases, the body loses resistance to the virus, leading to disease progression. [16] Elevated C-reactive protein is an important inflammatory index in addition to abnormal blood coagulation function. Close monitoring of dynamic changes in these indices has a significant proactive effect on understanding changes in the patient's condition.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 20 of the 78 patients (25.6%) developed respiratory failure, with the proportion of respiratory failure being significantly higher in the progression group than in the improvement/ stabilization group (54.5% vs. 20.9%, x 2 = 5.611, P = 0.028). The median RR of the 78 patients with COVID-19 was 24 breaths/min, and the RR in the progression group was significantly higher than in the improvement/stabilization group (34 [18,48] vs. 24 [16,60] breaths/min, U = 4.030, P = 0.004). There were no significant differences in blood oxygen saturation, or heart rate between the two groups (both P > 0.05).…”

Section: General Characteristics and Clinical Presentationsmentioning

confidence: 93%

Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease

Liu

Zhao

Wang

et al. 2020

Chinese Medical Journal

959

832

View full text Add to dashboard Cite

Individual data, laboratory indices, imaging characteristics, and clinical data were collected, and statistical analysis was performed. Based on clinical typing results, the patients were divided into a progression group or an improvement/stabilization group. Continuous variables were analyzed using independent samples t-test or Mann-Whitney U test. Categorical variables were analyzed using Chi-squared test or Fisher's exact test. Logistic regression analysis was performed to explore the risk factors for disease progression. Results: Seventy-eight patients with COVID-19-induced pneumonia met the inclusion criteria and were included in this study. Efficacy evaluation at 2 weeks after hospitalization indicated that 11 patients (14.1%) had deteriorated, and 67 patients (85.9%) had improved/stabilized. The patients in the progression group were significantly older than those in the disease improvement/ stabilization group (66 [51, 70] vs. 37 [32, 41] years, U = 4.932, P = 0.001). The progression group had a significantly higher proportion of patients with a history of smoking than the improvement/stabilization group (27.3% vs. 3.0%, x 2 = 9.291, P = 0.018). For all the 78 patients, fever was the most common initial symptom, and the maximum body temperature at admission was significantly higher in the progression group than in the improvement/stabilization group (38.2 [37.8, 38.6] vs. 37.5 [37.0, 38.4]°C, U = 2.057, P = 0.027). Moreover, the proportion of patients with respiratory failure (54.5% vs. 20.9%, x 2 = 5.611, P = 0.028) and respiratory rate (34 [18, 48] vs. 24 [16, 60] breaths/min, U = 4.030, P = 0.004) were significantly higher in the progression group than in the improvement/stabilization group. C-reactive protein was significantly elevated in the progression group compared to the improvement/stabilization group (38.9 [14.3, 64.8] vs. 10.6 [1.9, 33.1] mg/L, U = 1.315, P = 0.024). Albumin was significantly lower in the progression group than in the improvement/stabilization group (36.62 ± 6.60 vs. 41.27 ± 4.55 g/L, U = 2.843, P = 0.006). Patients in the progression group were more likely to receive high-level respiratory support than in the improvement/stabilization group (x 2 = 16.01, P = 0.001). Multivariate logistic analysis indicated that age (odds ratio [OR], 8.546; 95% confidence interval [CI]: 1.628-44.864; P = 0.011), history of smoking (OR, 14.285; 95% CI: 1.577-25.000; P = 0.018), maximum body temperature at admission (OR, 8.999; 95% CI: 1.036-78.147, P = 0.046), respiratory failure (OR, 8.772, 95% CI: 1.942-40.000; P = 0.016), albumin (OR, 7.353, 95% CI: 1.098-50.000; P = 0.003), and C-reactive protein (OR, 10.530; 95% CI: 1.224À34.701, P = 0.028) were risk factors for disease progression. Conclusions: Several factors that led to the progression of COVID-19 pneumonia were identified, including age, history of smoking, maximum body temperature at admission, respiratory failure, albumin, C-reactive protein. These results can be used to further enhance the ability of management of COVID-19 pneumon...

show abstract

“…Literature is still somewhat scarce in studies that have explored the relationship between the emotional life aspects of elderly cancer sufferers with their nutritional status. However, available evidence suggests that malnutrition increases by ve-fold the risk of depression in elderly patients undergoing chemotherapy [26]. The occurrence of gastrointestinal symptoms and the side-effects associated with cancer treatment reduce food intake and induce weight loss, impacting mobility and the capacity to perform daily-life activities.…”

Section: Discussionmentioning

confidence: 99%

A Poorer Nutritional Status Impacts Quality of Life in a Sample Population of Elderly Cancer Patients

Rios

Oliveira

Costa³

et al. 2020

Preprint

View full text Add to dashboard Cite

Rationale: Quality of Life (QoL) is impaired in cancer, and the elderly are particularly vulnerable to malnutrition. A diagnosis of cancer in elderly patients further exacerbate risks of negative health outcomes. Here we investigated associations between QoL and nutritional status in a sample population of mostly socially deprived elderly cancer patients.Method: 432 patients with diagnosed cancer were recruited for this cross-sectional study at point of admission to a tertiary referral charitable hospital for cancer treatment. Patient-Generated Subjective Global Assessment (PG-SGA) assessed nutritional status. Functional Assessment of Cancer Therapy- General (FACT-G) quantified QoL. PG-SGA outcomes were compared against FACT-G scores employing Mann-Whitney test. Relationship between PG-SGA and QoL scores was assessed by Spearman correlation. Bivariate Linear Regression Model was employed to investigate the influence of sociodemographic, clinical and nutritional status upon QoL.Results: 37.5% of participants were malnourished or at risk. 39% were illiterate and 54.6% had a family income lower than minimum wage. Malnourished patients showed lower FACT-G scores (78.0 vs. 86.0; p=0.000). Poor nutritional diagnosis was inversely correlated with all QoL domains. Bivariate regression analysis showed that worsened PG-SGA scores (βo = -1.00; p = 0.000) contributed to FACT-G score deterioration; the male gender showed less pronounced effects in QoL, whereas literacy and family income did not show relationship.Conclusion: We found that poorer nutritional status was significantly associated with worsened physical, social, emotional and functional well-being domains of QoL in elderly cancer patients. Future policies aimed at this particularly vulnerable population may improve QoL and health outcomes.

show abstract

Predictive factors of depressive symptoms of elderly patients with cancer receiving first-line chemotherapy

Cited by 36 publications

References 38 publications

Comparison of mood disorder screening scales in geriatric oncology: THYMOG study results

Comparison of mood disorder screening scales in geriatric oncology: THYMOG study results

Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease

A Poorer Nutritional Status Impacts Quality of Life in a Sample Population of Elderly Cancer Patients

Contact Info

Product

Resources

About