2022
DOI: 10.1177/08850666221093946
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Predictive Factors of Extubation Failure in COVID-19 Mechanically Ventilated Patients

Abstract: Purpose: We investigated whether COVID-19 patients on mechanical ventilation (MV) had a different extubation outcome compared to non-COVID-19 patients while identifying predictive factors of extubation failure in the former. Methods: A retrospective, single-center, and observational study was done on 216 COVID-19 patients admitted to an intensive care unit (ICU) between March 2020 and March 2021, aged ≥ 18 years, in use of invasive MV for more than 24 h, which progressed to weaning. The primary outcome that wa… Show more

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Cited by 7 publications
(9 citation statements)
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“…( 12 - 14 ) Guzatti et al found that the extubation failure rate was approximately three times higher during the ICU stay (22.1%) than during the 48-hour period (7.8%) after extubation and hypothesized that COVID-19 patients experience late extubation failure. ( 13 ) In our study, we did not find this trend of late extubation failure because 81% of the patients who required reintubation were reintubated within the first three days after extubation.…”
Section: Discussioncontrasting
confidence: 67%
“…( 12 - 14 ) Guzatti et al found that the extubation failure rate was approximately three times higher during the ICU stay (22.1%) than during the 48-hour period (7.8%) after extubation and hypothesized that COVID-19 patients experience late extubation failure. ( 13 ) In our study, we did not find this trend of late extubation failure because 81% of the patients who required reintubation were reintubated within the first three days after extubation.…”
Section: Discussioncontrasting
confidence: 67%
“…In general ICU populations, extubation failure occurs in 10-20% of invasively ventilated patients and is associated with mortality rates ranging from 25-50% [6]. Several observational studies found reintubation rates between 12-33% in patients with COVID-19, although timeframes and etiologies of failure varied in this research [7][8][9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…( 5 , 6 ) Em pacientes com doença causada pela doença pelo coronavírus 2019 (COVID-19), essa taxa é aproximadamente três vezes maior do que em pacientes sem COVID-19. ( 7 ) O fracasso da extubação está associado ao aumento da mortalidade hospitalar, ao prolongamento da internação na unidade de terapia intensiva (UTI) e ao aumento da necessidade de traqueostomia. ( 8 , 9 ) Entretanto, o prolongamento desnecessário da VM também está associado a um maior risco de infecção e mortalidade na UTI.…”
Section: Introductionunclassified
“…(5,6) In coronavirus disease 2019 (COVID- 19) patients, this rate is approximately three times higher than that in non-COVID-19 patients. (7) Extubation failure is associated with increased hospital mortality, prolonged intensive care unit (ICU) stay, and increased need for tracheostomy. (8,9) However, unnecessary prolongation of MV is also associated with an increased risk of infection and mortality in the ICU.…”
Section: Introductionmentioning
confidence: 99%