Predictive Factors of Gi Lesions in 241 Women With Iron Deficiency Anemia

Nahon, Stéphane; Lahmek, Pierre; Lesgourgues, Bruno; Nahon-Uzan, Karine; Tuszynski, Thierry; Traissac, L; Delas, Nicolas

doi:10.1111/j.1572-0241.2002.05534.x

Cited by 29 publications

(35 citation statements)

References 16 publications

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“…The prevalence of benign and malignant colorectal tumors (13% and 3%, respectively) was similar to other studies [10]. Furthermore the frequency of inflammatory GI lesions such as gastritis and esophagitis was more prevalent than GI ulcers and tumor lesions.…”

Section: Discussionsupporting

confidence: 72%

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Gastrointestinal Lesions in African American Patients with Iron Deficiency Anemia

Ashktorab¹

2017

Gastrointest Cancer Res Ther

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Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA associated gastrointestinal disorders are lacking among African American patients. Aim:To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Methods:We reviewed medical records (n=422) of patients referred for evaluation of IDA from 2008 to 2012. IDA was diagnosed using clinical laboratory tests. The results of esophagogastroduodenoscopy (EGD), colonoscopy and pathology specimens along with demographic data were abstracted and analyzed using STATA. Results:The mean age was 61.9 years, and 50.5% were female. 189 patients (45%) had gross GI bleeding. The most frequent diagnoses were gastritis (40%), benign colonic lesions (13%), esophagitis (9%), gastric ulcer (6%), and duodenitis (6%). By sex, duodenal benign tumors were significantly more represented among females: 4% vs 1% (p=0.05) while left colon malignancy was more prevalent among males: 3% vs 0.05% (p=0.05). Benign and malignant colonic lesions were significantly more present among older patients: 16% vs 6% (P=0.005) and 5% vs 0% (p=0.008), respectively. Colitis was more prevalent in younger patients (≤50): 11% vs 2% (p=0.001). In patients with gross lower GI bleeding, the top diagnoses were gastritis (25%), benign colon tumors (10%), and duodenitis (6%). Colon cancer was diagnosed among 15 patients and all these patients were older than 50 years of age. Conclusion:This exploratory analysis of IDA associated GI lesions revealed that gastritis and colonic lesions are most common lesions found among African Americans with IDA with minimal age and sex differences. Colitis was found more in young patients while IDA was more associated with lower GI malignancies in older patients. Upper GI endoscopy might be required if colonoscopy is unrevealing of the cause of IDA.

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Section: Discussionsupporting

confidence: 72%

“…Endoscopic evaluation should not be done in women without predictive factors; abdominal symptoms, age > 50yrs, and Hb < 9g/dl. Conversely, these factors are strongly associated with a GI lesion [10,11].…”

Section: Research Articlementioning

confidence: 97%

Gastrointestinal Lesions in African American Patients with Iron Deficiency Anemia

Ashktorab¹

2017

Gastrointest Cancer Res Ther

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“…This was similar to our result that more severe anemia (or lower serum ferritin level) also implied a greater chance for malignancy. Nahon et al [13] have reported age as a predictive factor of GI lesions in postmenopausal women with IDA. This was similar to our result that every increase of 1 year in age resulted in a risk of malignancy that was 1.062 times higher.…”

Section: Discussionmentioning

confidence: 99%

Predictive risk factors and prevalence of malignancy in patients with iron deficiency anemia in Taiwan

Chau

Hsu

et al. 2005

Am. J. Hematol.

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Gastrointestinal (GI) tract malignancy is one of the important causes of chronic iron deficiency anemia (IDA). The present study was designed to find out the prevalence and the predictive risk factors of malignancy in the IDA patients. We performed a prospective study in 148 patients with chronic IDA. A series of examinations to explore the GI tract were performed either by radiology and/or endoscopy. A Tc-RBC GI bleeding study was also performed, and prevalence and risk factors of malignancy were calculated. Totally 148 patients were enrolled, with mean age 66.2 years; 88 were male. Eighteen patients (12.2%) were found to have malignant tumors. Ten (6.8%) had benign tumors, and 96 (64.9%) had other benign conditions. No lesions could be detected in 24 patients (16.2%). Clinical symptoms and presence of fecal occult blood could not predict malignancy or any GI lesions. Multivariate logistic regression analysis showed serum ferritin £10 mg/L, LDH >250 U/L, and aging as the risk factors of malignancy in the IDA patients (P = 0.003, 0.002, and 0.027; and OR = 7.614, 8.955, and 1.062, respectively). An IDA patient with both serum ferritin £10 mg/L and LDH >250 U/L ran a 74.33-times higher risk of malignancy than the patient without (95% CI: 7.115-776.479). Malignancy was an important cause of IDA. High LDH, low serum ferritin, and aging were the risk factors of malignancy in the IDA patients. Am.

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“…Disorders of the GI tract causing iron deficiency by mechanisms of bleeding or iron malabsorption were reported in 12-95% of this population [2][3][4][5][6]. The information regarding the predictive value of GI symptoms on the incidence of GI findings in premenopausal women is limited; prior studies did not evaluate thoroughly IDA patients with and without symptoms.…”

Section: Introductionmentioning

confidence: 93%

Prevalence and Predictive Signs for Gastrointestinal Lesions in Premenopausal Women with Iron Deficiency Anemia

et al. 2008

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Predictive Factors of Gi Lesions in 241 Women With Iron Deficiency Anemia

Abstract: Endoscopy revealed a source of IDA in 49.4% of cases. Three predictive factors of GI lesion were identified. Endoscopic investigation should be avoided in women without these three predictive factors. Conversely, these factors are strongly associated with a GI lesion.

Cited by 29 publications

References 16 publications

Gastrointestinal Lesions in African American Patients with Iron Deficiency Anemia

Gastrointestinal Lesions in African American Patients with Iron Deficiency Anemia

Predictive risk factors and prevalence of malignancy in patients with iron deficiency anemia in Taiwan

Prevalence and Predictive Signs for Gastrointestinal Lesions in Premenopausal Women with Iron Deficiency Anemia

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