Predictive factors of lymphatic metastasis and evaluation of the Japanese treatment guidelines for endoscopic resection of early gastric cancer in a high-volume center in Perú

Torres, O.R. Paredes; Baca, Carlos; Cruz, Raúl; Paredes, Kori; Luque-Vasquez, Carlos; Chavez, Ivan; Taxa, Luis; Ruíz, Eloy; Berrospi, Francisco; Payet, Eduardo

doi:10.1016/j.heliyon.2023.e16293

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…We found that 9.2% of surgically resected EGC patients were staged with N+ disease. The frequency of N+ among EGCs is generally reported to be 10–15% [ 35 ], whereas some have reported a proportion as high as 20% [ 38 , 39 , 40 ]. To some surprise, of the eight patients with N+ status, four were staged with N2 disease and one was staged with N3 disease, with a correspondingly grave prognosis.…”

Section: Discussionmentioning

confidence: 99%

Early Gastric Cancers in Central Norway 2001 to 2016—A Population-Based Study

Kvamme,

Stillingen,

Sandø

et al. 2024

Cancers

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Early gastric cancers (EGCs) are confined to the gastric mucosa and submucosa irrespective of lymph node metastases and constitute only a minor proportion of gastric cancer in Western countries. We aimed to characterize EGCs and assess the survival of EGC in Central Norway during 2001–2016. A retrospective population-based study on 1205 patients with gastric cancer was performed. At the time, surgical resection was the standard treatment, and 88 (7.3%) EGCs were identified. Histopathological specimens were re-examined, and the eCura score and survival were evaluated. The number of gastric cancers declined (p = 0.010), but the relative proportion of EGC was unchanged during the study period. EGCs were more often of the Lauren intestinal type (p < 0.001) compared with controls. A significant proportion (9.4%, n = 5) of the patients with a low-risk eCura had lymph node metastases, whereas further exclusion of tumors with histological ulceration or SM2 invasion identified an N0 cohort. The median survival for EGC patients was 117.1 months (95% CI 99.8–134.3) and the 5-year overall survival was 75%. Twelve deaths were cancer-related, either due to postoperative complications (5.7%, n = 5) or cancer recurrence (8%, n = 7). In conclusion, EGCs constituted a minor but constant proportion of gastric cancers. eCura alone was insufficient in predicting patients with pN0 disease.

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Section: Discussionmentioning

confidence: 99%

Early Gastric Cancers in Central Norway 2001 to 2016—A Population-Based Study

Kvamme,

Stillingen,

Sandø

et al. 2024

Cancers

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“…EGC has a generally excellent prognosis, with the 5-year survival rate exceeding 90% after curative resection [2,3,5,10,16,19,29,[31][32][33][34][35][36]. This scenario can be changed by LNMs, because node-positive patients show a significant decline in survival expectancy [3,16].…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors for LNM are well established in Eastern countries [5,16,17]. Nevertheless, an analysis of predictive factors for LNMs in EGC remains uncommon in the West, where series of patients are smaller in comparison to the East [3,[17][18][19][20]. Moreover, the risk of LNMs in Western patients with EGC is higher, probably due to a higher incidence of T1b cancers [21,22].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Lymph Node Metastasis in a Western Series of Patients with Distal Early Gastric Cancer

Chiarello,

Vanella,

Fransvea

et al. 2024

JCM

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Background: Assessment of potential lymph node metastasis is mandatory in the appropriate treatment of early gastric cancers. This study analysed factors associated with lymph node metastasis to identify differences between node-negative and node-positive patients and between T1a and T1b cancers. Methods: The clinicopathological features of 129 early gastric cancer patients who had undergone radical gastrectomy were analysed to identify predictive factors for lymph node metastasis. Results: Lymph node metastasis was detected in 76 (59.0%) patients. Node-positive patients were younger (58.1 ± 11.3 years) than those without metastasis (61.9 ± 9.6 years, p = 0.02). Greater tumour sizes were observed in patients with lymph node metastasis (3.6 ± 1.0 cm) compared to node-negative patients (1.9 ± 0.5 cm, p = 0.00001). Depressed form, ulceration, diffuse histological type, and undifferentiated lesions were more frequent in node-positive patients than in the node-negative group. Tumour size > 3.0 cm showed a correlation with lymph node metastasis in both T1a (p = 0.0001) and T1b (p = 0.006) cancer. The male sex (p = 0.006) had a significant correlation with lymph node metastasis in T1a cancer. Depressed appearance (p = 0.02), ulceration (p = 0.03), differentiation (p = 0.0001), diffuse type (p = 0.0002), and lower third location (p = 0.005) were associated with lymph node metastasis in T1b cancer. Conclusions: Tumour size > 3 cm, undifferentiated lesions, ulceration, diffuse type, lower third location, and submucosal invasion are risk factors for lymph node metastasis in early gastric cancer.

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Risk factors for lymph node metastasis and invasion depth in early gastric cancer: Analysis of 210 cases

Xiang,

Yao

2024

World J Gastrointest Surg

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BACKGROUND Gastric cancer is the leading cause of cancer-related deaths worldwide. Early gastric cancer (EGC) is often associated with the risk of lymph node metastasis, which influences treatment decisions. Despite the use of enhanced computed tomography, the prediction of lymph node involvement remains challenging. AIM To investigate the risk factors for lymph node metastasis and invasion depth in patients with EGC. METHODS In total, 210 patients with pathologically diagnosed EGC were included in this study. Univariate and multivariate statistical analyses were used to predict risk factors for lymph node metastasis and invasion depth in patients with EGC. RESULTS Among the 210 patients, 27 (12.9%) had lymph node metastases. Of the 117 patients with submucosal gastric cancer, 24 (20.5%) had lymph node metastases. Both univariate and multivariate analyses indicated that the depth of invasion in EGC was a risk factor for lymph node metastasis in these patients. Additionally, pathological type was identified as a risk factor for cancer cell invasion in patients with EGC. CONCLUSION EGC invasion depth, not tumor type, size, age, sex, or location, predicts lymph node spread. Tumor type, not size, age, sex, or location, predicts cancer cell invasion.

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Predictive factors of lymphatic metastasis and evaluation of the Japanese treatment guidelines for endoscopic resection of early gastric cancer in a high-volume center in Perú

Cited by 4 publications

References 52 publications

Early Gastric Cancers in Central Norway 2001 to 2016—A Population-Based Study

Early Gastric Cancers in Central Norway 2001 to 2016—A Population-Based Study

Risk Factors for Lymph Node Metastasis in a Western Series of Patients with Distal Early Gastric Cancer

Risk factors for lymph node metastasis and invasion depth in early gastric cancer: Analysis of 210 cases

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