Predictive Factors of Major Adverse Cardiac Events in Acute Myocardial Infarction Patients Complicated by Cardiogenic Shock Undergoing Primary Percutaneous Coronary Intervention

Lim, Sang Yup; Jeong, Myung Ho; Bae, Eun Hui; Kim, Weon; Kim, Ju Han; Hong, Young Joon; Park, Hyung Wook; Kang, Dong Oh; Lee, Yeon Sang; Kim, Kye Hun; Lee, Sang Hyun; Yun, Kyung Ho; Hong, Seo Na; Cho, Jeong Gwan; Park, Jong Chun; Ahn, Byoung Hee; Kim, Sang Hyung; Kang, Jung Chaee

doi:10.1253/circj.69.154

Cited by 19 publications

(16 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29) On the other hand, it has also been demonstrated that high CRP levels both on admission 6) and at peak 30) are associated with the occurrence of mild to severe HF (Killip class II to IV) during the hospitalization period in AMI patients, and there are also studies in which higher admission CRP levels were observed in AMI patients who developed CS during the pre-or postadmission period. 8,9) In general, these observations are in agreement with our results. Nevertheless, to the best of our knowledge there are no studies examining the relationship between CRP levels and LVD when both of these factors were assessed on admission.…”

Section: Discussionsupporting

confidence: 93%

“…In these last studies, among AMI patients with pre-or postadmission CS who underwent primary PCI, CRP level was associated with in-hospital mortality and was an independent predictor of 1-year major adverse cardiac events. 8,9) In conclusion, for the time point of hospital admission, CRP level is associated with the occurrence of both HF and CS and PAI-1 level is associated with the occurrence of CS after AMI, and both of these markers are independent predictors of in-hospital and 1-year mortality in CS complicating AMI.…”

Section: Discussionmentioning

confidence: 86%

“…While elevated levels of circulating CRP on admission have been rather clearly demonstrated to be an independent predictive factor for adverse outcomes both for hospital stay and longer time periods in ACS patients or specifically in AMI patients, [3][4][5][6][7] this association has been reported only for the hospital stay 10,12) and for 30-day follow-up 14) for PAI-1. However, to our knowledge, there are only two studies 8,9) addressing the relationship between CRP levels on admission and clinical outcomes and no studies addressing this issue for PAI-1 in patients with CS complicating AMI. In these last studies, among AMI patients with pre-or postadmission CS who underwent primary PCI, CRP level was associated with in-hospital mortality and was an independent predictor of 1-year major adverse cardiac events.…”

Section: Discussionmentioning

confidence: 99%

“…7) Accordingly, there are studies reporting high CRP levels on admission among patients with CS complicating AMI. 8,9) In these studies, it has also been shown that this measurement of CRP is associated with short-and long-term outcomes in CS patients. 8,9) On the other hand, admission levels of plasminogen activator inhibitor-1 (PAI-1), which is a key regulator of the fibrinolytic system, have also been shown to be elevated [10][11][12][13] and associated with adverse outcomes 10,12,14) in AMI patients.…”

mentioning

confidence: 96%

See 3 more Smart Citations

Admission Levels of C-Reactive Protein and Plasminogen Activator Inhibitor-1 in Patients With Acute Myocardial Infarction With and Without Cardiogenic Shock or Heart Failure on Admission

et al. 2009

View full text Add to dashboard Cite

SummaryScarce data exist on the relationship of C-reactive protein (CRP) or plasminogen activator inhibitor-1 (PAI-1) to the occurrence of heart failure (HF) or cardiogenic shock (CS) after acute myocardial infarction (AMI) and on the relationship between these biomarkers and mortality in CS patients. Thus, we compared high-sensitivity CRP and PAI-1 antigen plasma levels on admission among 3 age-and gender-matched AMI patients groups (consisting of 60 patients with CS, 60 with HF, and 60 without HF on admission), after determining that PAI-1 levels did not vary significantly diurnally in these groups by comparing the data among subgroups which were divided according to admission time within the groups. For CS patients, we also conducted regression analyses to examine the relations of these biomarkers to mortality. CRP levels both in CS (P < 0.001) and HF (P < 0.05) patients were significantly higher compared to those without HF, PAI-1 levels in CS patients were significantly higher compared to both those with (P < 0.05) and without HF (P < 0.01), and CRP and PAI-1 were independent predictors of in-hospital (Odds ratio [OR] = 6.12, 95% confidence intervals [95%CI] = 1.47-25.54 and OR = 5.92, 95%CI = 1.31-26.77, respectively) and 1-year mortality (OR = 5.53, 95%CI = 1.21-25.17 and OR = 5.48, 95%CI = 1.09-27.52, respectively) in CS patients. In conclusion, at admission, CRP is associated with the occurrence of CS and HF and PAI-1 is associated with the occurrence of CS after AMI, and they are of prognostic value in CS complicating AMI. (Int Heart J 2009; 50: 33-45)

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

See 2 more Smart Citations

Admission Levels of C-Reactive Protein and Plasminogen Activator Inhibitor-1 in Patients With Acute Myocardial Infarction With and Without Cardiogenic Shock or Heart Failure on Admission

et al. 2009

View full text Add to dashboard Cite

show abstract

“…19 In the other study, 3 of 121 hospital survivors died from cardiac causes up to 1 y of follow-up. 26 Furthermore, in unselected post-MI patients, 50%-60% of deaths during longterm follow-ups have been attributed to cardiac causes. 21,27 It is noteworthy that, in our study, just over 50% of patients developed chronic congestive heart failure.…”

Section: Discussionmentioning

confidence: 99%

Long‐Term Survival and Outcomes After Hospitalization for Acute Myocardial Infarction Complicated by Cardiogenic Shock

Drakos

Bonios

Anastasiou-Nana

et al. 2009

Clinical Cardiology

View full text Add to dashboard Cite

Background: Cardiogenic shock is the leading cause of death during hospitalization for acute myocardial infarction (MI). However, little data exist regarding the long-term outcomes of patients who survived the acute phase of MI and were discharged from the hospital. Methods: We retrospectively reviewed the records of 81 consecutive patients referred for management of acute MI and cardiogenic shock to analyze their in-hospital and long-term outcomes. Results: Mean systemic systolic and central venous pressures at presentation were 74±15 and 17±7 mm Hg, respectively. Intra-aortic balloon counterpulsation (IABC) was implemented in all patients for a mean of 88±83 hours. Thrombolytics were administered in 49% and mechanical ventilation applied in 46% of patients. Primary angioplasty could not be performed in any patient, while 17 patients later underwent myocardial revascularization during hospitalization. There were 37 in-hospital survivors (45.7%). The 1-year survival after discharge from the hospital was 87.6% in the overall population, versus 100% among patients who underwent in-hospital myocardial revascularization, versus 78.9% among nonrevascularized patients (p = 0.079). Over a mean follow-up of 85±47 mo, survival after discharge from the index hospitalization was 44.9% in the overall population, versus 56.2% among revascularized patients, versus 36.4% among nonrevascularized patients (p = 0.277). Heart failure developed in 51.6% of patients who were discharged from the hospital. Conclusions: In this single center analysis, the long-term survival after acute MI complicated by cardiogenic shock was high with nearly 50% of patients surviving free from heart failure. IntroductionCardiogenic shock, the leading cause of death of patients presenting with acute myocardial infarction (MI), occurs in 5% to 10% of patients, two-thirds of whom die within a few weeks. 1,2 Recent observations, however, suggest that the introduction of more invasive management strategies in patients with acute MI is decreasing mortality from cardiogenic shock.3 -6 Current practice guidelines recommend the prompt reestablishment of blood flow across the infarctrelated artery in the management of shock due to right or left ventricular failure. 7 -9 However, most studies of cardiogenic shock have focused on the impact of various treatment modalities on short-term outcomes without examining the long-term prognosis of hospital survivors. The purpose of the present single center study was to evaluate the longterm outcomes of patients who survived the acute phase of cardiogenic shock due to acute MI.

show abstract

Predictors of in-hospital mortality in patients with acute myocardial infarction complicated by cardiogenic shock in the contemporary era of primary percutaneous coronary intervention

Ong

Arasaratnam

et al. 2014

IJC Heart & Vessels

View full text Add to dashboard Cite

Predictive Factors of Major Adverse Cardiac Events in Acute Myocardial Infarction Patients Complicated by Cardiogenic Shock Undergoing Primary Percutaneous Coronary Intervention

Cited by 19 publications

References 40 publications

Admission Levels of C-Reactive Protein and Plasminogen Activator Inhibitor-1 in Patients With Acute Myocardial Infarction With and Without Cardiogenic Shock or Heart Failure on Admission

Admission Levels of C-Reactive Protein and Plasminogen Activator Inhibitor-1 in Patients With Acute Myocardial Infarction With and Without Cardiogenic Shock or Heart Failure on Admission

Long‐Term Survival and Outcomes After Hospitalization for Acute Myocardial Infarction Complicated by Cardiogenic Shock

Predictors of in-hospital mortality in patients with acute myocardial infarction complicated by cardiogenic shock in the contemporary era of primary percutaneous coronary intervention

Contact Info

Product

Resources

About