Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma

Fiore, Frédéric Di; Lecleire, Stéphane; Rigal, Olivier; Galais, Marie-Pierre; Soussan, Emmanuel Ben; David, Isabelle; Paillot, B; Jacob, Jacques-Henri; Michel, Pierre

doi:10.3748/wjg.v12.i26.4185

Cited by 66 publications

(58 citation statements)

References 38 publications

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“…We observed a median os duration of 28 months in the cisplatin-5fu group, which is similar to the 25-26 months reported in more recent literature 15,22,23 . Known prognostic factors such as performance status, tumour length, clinical stage, histology, and age were considered in the multivariate model that confirmed the association of a survival benefit with cisplatin-5fu 16,24 . Although not statistically significant, a trend toward better local control and less distant metastasis was also observed for the cisplatin-5fu group, which supported our finding that the survival benefit observed in the cisplatin-5fu group was likely attributable to a better treatment outcome rather than to selection of fitter patients.…”

Section: Discussionmentioning

confidence: 99%

Shifting Practice in Definitive Chemoradiation for Localized Esophageal Cancer

Biagi

Hopman

et al. 2017

Current Oncology

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Section: Discussionmentioning

confidence: 99%

Shifting Practice in Definitive Chemoradiation for Localized Esophageal Cancer

Biagi

Hopman

et al. 2017

Current Oncology

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“…5 Diets high in fruits and vegetables are protective against most cancers of the head and neck, 6 can affect the occurrence of second primary cancers, 7 and are associated with reduced cancer mortality. 5 Malnutrition, 8 cachexia, 9 and weight loss 10 are poor prognostic indicators for head and neck cancer patients. There is also evidence that a sedentary lifestyle may promote certain types of cancer, such as colon or breast 11 ; however, the association with physical activity and head and neck cancer is less clear.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Health Behaviors Predict Survival Among Patients With Head and Neck Squamous Cell Carcinoma

Duffy

Ronis

McLean

et al. 2009

JCO

138

150

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A B S T R A C T PurposeOur prior work has shown that the health behaviors of head and neck cancer patients are interrelated and are associated with quality of life; however, other than smoking, the relationship between health behaviors and survival is unclear. Patients and MethodsA prospective cohort study was conducted to determine the relationship between five pretreatment health behaviors (smoking, alcohol, diet, physical activity, and sleep) and all-cause survival among 504 head and neck cancer patients. ResultsSmoking status was the strongest predictor of survival, with both current smokers (hazard ratio [HR] ϭ 2.4; 95% CI, 1.3 to 4.4) and former smokers (HR ϭ 2.0; 95% CI, 1.2 to 3.5) showing significant associations with poor survival. Problem drinking was associated with survival in the univariate analysis (HR ϭ 1.4; 95% CI, 1.0 to 2.0) but lost significance when controlling for other factors. Low fruit intake was negatively associated with survival in the univariate analysis only (HR ϭ 1.6; 95% CI, 1.1 to 2.1), whereas vegetable intake was not significant in either univariate or multivariate analyses. Although physical activity was associated with survival in the univariate analysis (HR ϭ 0.95; 95% CI, 0.93 to 0.97), it was not significant in the multivariate model. Sleep was not significantly associated with survival in either univariate or multivariate analysis. Control variables that were also independently associated with survival in the multivariate analysis were age, education, tumor site, cancer stage, and surgical treatment. ConclusionVariation in selected pretreatment health behaviors (eg, smoking, fruit intake, and physical activity) in this population is associated with variation in survival.

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“…The prognosis of esophageal cancer remains poor with a 5-year overall survival rate of less than 20% (3,4). Although curative surgery is a treatment for patients with resectable esophageal cancer, approximately 50% of patients have unresectable locally advanced tumor invading the adjacent organs or radiographically visible metastases (5).…”

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confidence: 99%

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Sato

Kunisaki

Suematsu

et al. 2018

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Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma

Abstract: Our results suggest that survival in patients with LASCOC treated with definitive CRT was correlated to CCR, weight loss and WHO performance status.

Cited by 66 publications

References 38 publications

Shifting Practice in Definitive Chemoradiation for Localized Esophageal Cancer

Shifting Practice in Definitive Chemoradiation for Localized Esophageal Cancer

Pretreatment Health Behaviors Predict Survival Among Patients With Head and Neck Squamous Cell Carcinoma

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

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