Predictive Factors of Tumor Shrinkage and Histological Regression in Patients who Received Preoperative Radiotherapy for Rectal Cancer

Suzuki, Toshiyuki; Sadahiro, Sotaro; Fukasawa, Maki; Ishikawa, Kenji; Kamijo, Akemi; Yasuda, Seiei; Makuuchi, Hiroyasu; Ohizumi, Yukio; Murayama, Chieko

doi:10.1093/jjco/hyh140

Cited by 27 publications

(27 citation statements)

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“…However, in other reports, no relation was noted between Ki67 values in biopsy specimens before radiation and response rate in rectal cancers (Suzuki et al, 2004;Debucquoy et al, 2008). Suzuki et al (2004) performed preoperative radiotherapy only. Debucquoy et al (2008) combined preoperative radiotherapy and/or 5-FU/LV.…”

Section: Discussionmentioning

confidence: 80%

“…Later, beneficial effects of radiotherapy for patients with various carcinoma with high Ki67 LIs were reported (Nakano et al, 1997;Raybaud-Diogene et al, 1997). However, in other reports, no relation was noted between Ki67 values in biopsy specimens before radiation and response rate in rectal cancers (Suzuki et al, 2004;Debucquoy et al, 2008). Suzuki et al (2004) performed preoperative radiotherapy only.…”

Section: Discussionmentioning

confidence: 99%

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High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction

et al. 2009

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BACKGROUND: Recently, preoperative chemoradiation therapy (CRT) for rectal cancer has been increasingly used as a neoadjuvant treatment. In the present study, the relation between histological response to CRT and immunohistochemical markers in biopsy specimens was investigated. METHODS: Biopsy specimens from a total of 60 patients were collected before preoperative CRT with S-1 and irinotecan, and liniac 45 Gy. Immunohistochemical staining for Ki67, Mcm3, Bax, Bcl-2, ssDNA, Grp78, thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), CD34, vascular endothelial growth factor, nestin, and L-type amino-acid transporter 1 was performed to allow comparison of the Ki67 labelling index (LI), Bax score, TS score, DPD score, microvessel density by CD34, and Grp78 score with cancer regression. RESULTS: When the cases were divided into responders (Dworak grades 3 and 4) and non-responders (grades 1 and 2) groups, good correlations were evident with Ki67 LI, Bax, Grp78, and TS expression. On multiple logistic regression analysis, Ki67 LI, Bax, and TS scores were found to be independent factors. With their use in a logistic model, P-values could predict responder cases with a sensitivity of 82.8% and a specificity of 83.9%. CONCLUSION: Using this system, treatment strategy for locally advanced rectal cancers can be determined before chemoradiation.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction

et al. 2009

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“…This was to avoid therapy-induced changes which would have interfered with targeted tumour cells in subsequent immunohistochemical staining (Suzuki et al, 2004;Schneider et al, 2005). Any previous treatment would also have altered normal lymphatic drainage, resulting in unusual distribution of regional spread of disease (Edge et al, 2010).…”

Section: Inclusion Criteriamentioning

confidence: 99%

Changed Expression of E-cadherin and Galectin-9 in Oral Squamous Cell Carcinomas but Lack of Potential as Prognostic Markers

Kallarakkal²,

Abraham³

2014

Asian Pacific Journal of Cancer Prevention

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Background: The survival rate for oral squamous cell carcinoma (OSCC) has remained generally unchanged in the past three decades, underlining the need for more biomarkers to be developed to aid prognostication and effective management. The prognostic potential of E-cadherin expression in OSCCs has been variable in previous studies while galectin-9 expression has been correlated with improved prognosis in other cancers. The aim of the present study was to investigate the expression of galectin-9 and E-cadherin in OSCC and their potential as prognostic biomarkers. Materials and Methods: E-cadherin and Galectin-9 expression was examined by immunohistochemistry in 32 cases of OSCC of the buccal mucosa (13 with and 19 without lymph node metastasis), as well as 6 samples of reactive lesions and 5 of normal buccal mucosa. Results: The expression of E-cadherin in OSCC was significantly lower than the control tissues but galectin-9 expression was conversely higher. Median E-cadherin HSCOREs between OSCCs positive and negative for nodal metastasis were not significantly different. Mean HSCOREs for galectin-9 in OSCC without lymph node metastasis (127.7±81.8) was higher than OSCC with lymph node metastasis (97.9±62.9) but this difference was not statistically significant. Conclusions: E-cadherin expression is reduced whilst galectin-9 expression is increased in OSCC. However, the present results suggest that E-cadherin and galectin-9 expression may not be useful as prognostic markers for OSCC.

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“…It is possible that immunohistochemical evaluation or molecular biology techniques applied to pre-operative biopsy samples may prove to be of predictive value in the future [21,34,52,75] . Undoubtedly, histopathological evaluation of the neoplastic tissue regression following preoperative radiotherapy is very important and necessary, since ultrasound examination here is of limited reliability.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of two independent histopathological classifications of tumor regression in patients with rectal cancer submitted to hyperfractionated pre-operative radiotherapy

Liszka

Zielińska-Pająk²,

Pajak³

et al. 2007

WJG

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INTRODUCTIONColorectal cancer is the third most common malignancy diagnosed in the USA [1] . The estimated colorectal cancer mortality in the USA in 2006 is 55 170 [2] . The primary treatment method for rectal cancer is surgery, namely anterior rectal resection, abdomino-perineal resection or local excision [3][4][5][6] . Preoperative radiotherapy and radiochemotherapy play an increasing role in the treatment of rectal cancer [7][8][9][10][11][12][13] . The effectiveness of neo-adjuvant therapy may be assessed and monitored by means of longterm survival follow up, incidence of local recurrence, estimation of the percentage of patients with primary high stage tumor suitable for radical surgery, estimation of the percentage of patients suitable for sphincter-saving surgery or by monitoring the tumor stage using visualizing diagnostic methods [14,15] . Transrectal ultrasound (TRUS) is a useful method for the assessment of the local tumor stage and the regional lymph node status prior to neo-adjuvant therapy [3,4,6,16] . Basing on TRUS and histopathological examination one can define the tumor reg ression parameter "T-downstaging". Lower ypT parameter value (local tumor stage assessed by the pathologist in surgical specimen following neo-adjuvant therapy) than uT (local Abstract AIM: To assess the usefulness of two independent histopathological classifications of rectal cancer regression following neo-adjuvant therapy. METHODS:Forty patients at the initial stage cT3NxM0 submitted to preoperative radiotherapy (42 Gy during 18 d) and then to radical surgical treatment. The relationship between "T-downstaging" versus regressive changes expressed by tumor regression grade (TRG 1-5) and Nasierowska-Guttmejer classification (NG 1-3) was studied as well as the relationship between TRG and NG versus local tumor stage ypT and lymph nodes status, ypN. RESULTS:Complete regression (ypT0, TRG 1) was found in one patient. "T-downstaging" was observed in 11 (27.5%) patients. There was a weak statistical significance of the relationship between "T-downstaging" and TRG staging and NG stage. Patients with ypT1 were diagnosed as TRG 2-3 while those with ypT3 as TRG5.No lymph node metastases were found in patients with TRG 1-2. None of the patients without lymph node metastases were diagnosed as TRG 5. Patients in the ypT1 stage were NG 1-2. No lymph node metastases were found in NG 1. There was a significant correlation between TRG and NG. CONCLUSION:Histopathological classifications may be useful in the monitoring of the effects of hyperfractionated preoperative radiotherapy in patients

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Predictive Factors of Tumor Shrinkage and Histological Regression in Patients who Received Preoperative Radiotherapy for Rectal Cancer

Abstract: Histological examination of apoptosis, p21 and p53 in biopsy specimens and scoring were considered to be useful predictive methods for assessing the efficacy of radiotherapy for rectal cancer.

Cited by 27 publications

References 22 publications

High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction

High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction

Changed Expression of E-cadherin and Galectin-9 in Oral Squamous Cell Carcinomas but Lack of Potential as Prognostic Markers

Usefulness of two independent histopathological classifications of tumor regression in patients with rectal cancer submitted to hyperfractionated pre-operative radiotherapy

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