Predictive model for early death risk in pediatric hemophagocytic lymphohistiocytosis patients based on machine learning

Xiao, Li; Zhang, Yang; Xu, Ximing; Dou, Ying; Guan, Xianmin; Guo, Yuxia; Wen, Xianhao; Meng, Yan; Liao, Meiling; Hu, Qinshi; Yu, Jie

doi:10.1016/j.heliyon.2023.e22202

Cited by 3 publications

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Health‐Related Quality of Life Among Discharged Patients With Hemophagocytic Lymphohistiocytosis: A Follow‐Up Study

Li,

Yu,

Yan

et al. 2024

Pediatric Blood & Cancer

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PurposeEvaluating the post‐discharge health‐related quality of life (HRQoL) in hemophagocytic lymphohistiocytosis (HLH) and exploring its influencing factors.Patients and MethodsThe study was conducted at a regional pediatric medical center and involved pediatric patients diagnosed with HLH between July 2017 and July 2022. Healthy children of the same age and sex were included as the control group. The HRQoL and its associated factors in pediatric patients were assessed using the PedsQL 4.0 Parent Proxy Report and a general information survey.ResultsIn the first year following diagnosis, psychological health and overall score in HLH patients were worse than those of the control group. However, scores for emotional functioning, school functioning, physical health, psychosocial health, and overall scores in the HLH group increased over the years since diagnosis. By the 5‐year post diagnosis, there were no significant differences between the HLH group and the control group in social functioning, school functioning, physical health, psychosocial health, and overall scores (p > 0.05). Generalized linear model analysis revealed that HLH patients who underwent transplantation have worse social functioning, physical health, overall score, while HLH patients with HLH recurrence have worse social functioning, psychosocial health, overall score (p < 0.05).ConclusionThe HRQoL of HLH patients is compromised after discharge; however, it progressively returns to levels comparable to those of healthy cohorts over time since diagnosis. Transplantation, and HLH recurrence are identified as factors affecting the HRQoL in HLH patients.

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