2017
DOI: 10.1111/ajt.14108
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Predictive Modeling of Tacrolimus Dose Requirements: “All That Is Gold Does Not Glitter”

Abstract: We read, with interest, the paper by Damon et al on predictive models based on selected gene variants that explain variability in tacrolimus dose-corrected trough levels (C 0 ) in renal recipients (1). We want to share some of our critiques regarding methodology and interpretation of data.First, we suggest not using the term "predictive modeling" in a setting of multiple gene variant sets that variably associate with concurrent tacrolimus C 0 at different time points after transplantation. Validation of predic… Show more

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