Predictive Performance and Optimal Cut-Off Points of Blood Pressure for Identifying Arteriosclerosis among Adults in Eastern China

Abstract

This study aimed to assess the predictive performance and establish optimal cut-off points of blood pressure for identifying arteriosclerosis in eastern Chinese adults. Brachial–ankle pulse wave velocity (baPWV) was utilized to evaluate arteriosclerosis. The predictive performance of blood pressure for arteriosclerosis was determined by the area under the curve (AUC) of receiver operating characteristics; the optimal blood pressure cut-off points were determined by Youden’s index. A logistic regression model was used to acquire the odds ratio (OR) of blood pressure for arteriosclerosis. The AUCs of blood pressure for identifying arteriosclerosis were 0.868 (95%CI: 0.860–0.875) for systolic blood pressure (SBP) and 0.835 (95%CI: 0.827–0.843) for diastolic blood pressure (DBP), both p < 0.01. The AUCs of women were higher than that of men (0.903 vs. 0.819 for SBP; 0.847 vs. 0.806 for DBP; Z test p < 0.05). The AUCs in the 18–39.9-years group were higher than that in the 40–59.9-years and 60–84-years groups (0.894 vs. 0.842 and 0.818 for SBP; 0.889 vs. 0.818 and 0.759 for DBP; Z test p < 0.05). The total optimal cut-off points of blood pressure for predicting arteriosclerosis were 123.5/73.5 mmHg (SBP/DBP) overall; 123.5/73.5 and 126.5/79.5 mmHg for women and men, respectively; and 120.5/73.5, 123.5/76.5, and 126.5/75.5 mmHg for 18–39.9-years, 40–59.9-years, and 60–84-years groups, respectively. Blood pressure indexes had a high predictive performance for identifying arteriosclerosis with the optimal cut-off point of 123.5/73.5 mmHg (SBP/DBP) in eastern Chinese adults. Women or the younger population have a higher predictive performance and lower cut-off points to identify arteriosclerosis.

Interaction Between Obesity and Hypertension on Arteriosclerosis in Chinese Urban Adults: A Population-Based Cross-Sectional Study

“…CVD and obesity are two major threats to public health (He et al, 2022). Arteriosclerosis is the dominant cause of CVD (Gavornik & Galbavy, 2001; Yu et al, 2021). In this study, the results of the two-way ANOVA and the unconditional logistic regression models showed that hypertension was statistically significant in both baPWV and arteriosclerosis, which may suggest that hypertension is a crucial factor influencing arteriosclerosis.…”

“…Both sides are measured and the abnormal side is taken for the analysis. Arteriosclerosis was defined as a baPWV ≥ 1400 cm/s (Yu et al, 2021). The ABI was calculated by dividing the SBP at the ankle by the SBP in the arm (Al-Qaisi et al, 2009).…”

“…Other information in the study including sex, age, RHR, smoking status, and exercise status was collected by questionnaires. The smoking status was defined as those who smoke at least one cigarette per day continuously or cumulatively for 6 months (Yu et al, 2021; Yuan et al, 2019). Exercise status was defined as those who exercise through at least 30 minutes of moderate-intensity physical activity three times per week (Garber et al, 2011; Yu et al, 2021; Zhao, 2011).…”

“…The smoking status was defined as those who smoke at least one cigarette per day continuously or cumulatively for 6 months (Yu et al, 2021; Yuan et al, 2019). Exercise status was defined as those who exercise through at least 30 minutes of moderate-intensity physical activity three times per week (Garber et al, 2011; Yu et al, 2021; Zhao, 2011). In this study, participants’ ages ranged from 18 to 84 years.…”

“…Arteriosclerosis is a vascular disease characterized by thickening, hardening, and remodeling of arterial walls, and considered the dominant cause of cardiovascular disease (CVD) (Gavornik & Galbavy, 2001; Yu et al, 2021). Brachial–ankle pulse wave velocity (baPWV) is the most widely used measure of arteriosclerosis in regular clinical and epidemiological settings (Zheng et al, 2015).…”