Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers

Abstract

Performance of the Domino model during control of low-dose ketamine infusions was sub-optimal. The Clements 250 model may be a better model for controlling low-dose TCI ketamine administration.

Test–retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers

“…Nevertheless, this does not detract from the main aim of this paper which was to assess the reliability of the BOLD phMRI response to ketamine. Plasma concentrations measured in a separate cohort were consistent with the expected exposure based on the Clements 250 model (Absalom et al, 2007).…”

“…For each participant, the ketamine doses administered were the same on both testing sessions. The infusion parameters used were based on the Clements 250 infusion model (Absalom et al, 2007) implemented in Stanpump software (www.opentci.org) running in Windows Vista. To achieve the target plasma levels, the ketamine doses delivered were (mean ± standard deviation) 0.08 ± 0.0022 mg/kg during the first minute followed by approximately 0.23 mg/kg/h (for 50 ng/mL target plasma concentration) and 0.12 ± 0.0026 mg/kg during the first minute followed by 0.31 mg/kg/h (for 75 ng/mL target plasma concentration).…”

Effects of Acute Ketamine Infusion on Visual Working Memory: Event-Related Potentials

“…which was shown to reliably predict ketamine plasma concentrations (i.e., within 2 SD of the observed plasma concentration) (58). To achieve the target plasma levels, the ketamine doses delivered were 0.16 mg/kg 6 0.0028 (mean 6 SD) during the first minute followed by approximately 0.39 mg/kg/hour (for 100 ng/mL target plasma concentration).…”

Modulatory effects of ketamine, risperidone and lamotrigine on resting brain perfusion in healthy human subjects

“…Following a short break for lunch, the second part of the MRI protocol included an intravenous infusion of either ketamine (3/4 sessions) or saline (1/4 sessions). Racemic ketamine (Ketalar; Pfizer, New York, NY) was administered using a computer-controlled pump (Graseby 3400; Smiths Medical, Kent, UK) programmed (Stanpump; www.opentci.org) using the Clements 250 model (Clements and Nimmo 1981;Absalom et al 2007) to deliver a target plasma concentration of 75 ng/mL based on the individual subject's height and weight.…”