2018
DOI: 10.1182/blood-2018-99-118363
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Predictive Response Biomarkers for BET Inhibitors in AML

Abstract: BACKGROUND: Despite mounting knowledge, the management of patients with acute myeloid leukemia (AML) can be challenging, particularly for relapsed/refractory patients who lack innovative, effective treatments. Recent preclinical studies of AML have demonstrated promissory therapeutic activity of the novel class of inhibitors of bromodomain and extra terminal (BET) family proteins. To identify AML patients that may benefit from BET inhibitor treatment, we sought to discover and evaluate predictive molecular bio… Show more

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“…With a general trend towards whole transcriptome RNA sequencing (Arindrarto et al, 2020) and other high-throughput biomarker discovery (Bai et al, 2013;Drenberg et al, 2019;Prashad et al, 2016;Saad et al, 2018), the profiling of genes such as PARP1 that is associated with cytarabineinduced parthanatos may provide a practical means for patient stratification. Indeed, PARP-1 is known to play a central role in parthanatos, DNA damage repair, and hematopoietic differentiation (Gil-Kulik et al, 2020;Hsieh et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…With a general trend towards whole transcriptome RNA sequencing (Arindrarto et al, 2020) and other high-throughput biomarker discovery (Bai et al, 2013;Drenberg et al, 2019;Prashad et al, 2016;Saad et al, 2018), the profiling of genes such as PARP1 that is associated with cytarabineinduced parthanatos may provide a practical means for patient stratification. Indeed, PARP-1 is known to play a central role in parthanatos, DNA damage repair, and hematopoietic differentiation (Gil-Kulik et al, 2020;Hsieh et al, 2017).…”
Section: Discussionmentioning
confidence: 99%