Predictive role of laboratory markers and clinical features for recurrent Henoch-Schönlein Purpura in childhood: A study from Turkey

Gökçe, Şule; Kurugöl, Zafer; Koturoğlu, Güldane; Aslan, Aslı

doi:10.1080/14397595.2019.1690966

Cited by 9 publications

(11 citation statements)

References 19 publications

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“…Calvo Rio et al found that articular and GI manifestations, and a history of previous infection at the time of the diagnosis, were independent predictive factors for IgA vasculitis relapses 15 . Gökçe et al 16 studied 99 children and found that the risk of relapse increased 17.2‐fold in children with IgA vasculitis involving skin, joints, kidneys and the GI system. The correlation between the use of corticosteroids and recurrence has not yet been established, because study results have not been in agreement 6 …”

Section: Resultsmentioning

confidence: 99%

Gastrointestinal involvement in childhood vasculitides

2020

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Aim: The aim of this narrative review was to provide a comprehensive summary of the characteristics of gastrointestinal (GI) involvement in the most common paediatric primary vasculitides. Methods: We used PubMed to primarily identify papers, reviews, case series and editorials published in English from 2000 until 31 January 2020. Based on this, we report the prevalence, clinical manifestations, diagnostic approaches and management of GI involvement in each vasculitis. Results: Vasculitides are inflammatory blood vessel diseases, and the majority can affect the GI system with vascular, GI tract or solid organ involvement. GI involvement can sometimes complicate and delay the correct diagnosis. Clinical findings are usually nonspecific symptoms, such as fever, abdominal pain, nausea, vomiting and diarrhoea. Bleeding should alert paediatricians to the possibility of severe complicated vasculitis. Diagnosis relies mostly on imaging. If it goes unrecognised, GI involvement in paediatric vasculitis is a serious cause of morbidity and even mortality, related to bowel ischaemia and perforation. Treatment of GI symptoms depends on the type of vasculitis and usually involves high-dose steroids and immunosuppressants. Conclusion: GI manifestations in the most common paediatric primary vasculitides were usually nonspecific, diagnosis mostly relied on imaging, and treatment usually involved high-dose corticosteroids and immunosuppressants. K E Y W O R D S childhood, gastrointestinal involvement, immunosuppressant, steroids, vasculitis | 2227 TRAPANI eT Al. paralytic ileus, mesenteric ischaemia, bowel obstruction and perforation. Occasionally, GI involvement can be the presenting feature, and this can complicate and delay the correct diagnosis. The aim of this narrative review was to provide a comprehensive summary and update of the characteristics of GI involvement in the most common paediatric primary vasculitis. 2 | ME THODS We used PubMed to primarily identify papers, reviews, case series and editorials published in English from 2000 until 31 January 2020. The keywords included the following: IgA vasculitis, Henoch-Schonlein purpura, Kawasaki disease, Behcet disease, polyarteritis nodosa, Takayasu arteritis, deficiency of adenosine deaminase 2, antineutrophilic cytoplasmic antibodies-associated vasculitis, gastrointestinal, gut, child and paediatric or paediatric.

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Section: Resultsmentioning

confidence: 99%

Gastrointestinal involvement in childhood vasculitides

2020

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“…Numerous foreign studies have confirmed that IgAV recurrence can result in kidney injury in children with IgAV and the recurrence rate ranges from 10.25 to 25% [ 11 , 12 , 22 ]. In the present study, we found that the recurrence rate was 20.2%, which was consistent with previous findings.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we did not observe the correlation between age and IgAV recurrence, which may be due to the limited small sample size or differences in allocation. Additionally, some studies have shown a correlation between different locations/systems, such as skin, kidney, joint, and gastrointestinal tract, or different numbers of these systems and IgAV recurrence [ 12 ]. In the present study, joint involvement was an independent predictive factor for IgAV recurrence (OR: 2.596, 95% CI: 1.097–6.147; P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…IgA vasculitis (IgAV) is a common type of vascular inflammation that mainly affects children; however, its cause and pathogenesis remain poorly understood. It also affects adults, but the incidence of the disease is high in children (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) per 100,000 person-years). Although it usually has a favorable prognosis, the recurrence rate is Common laboratory indices, such as C-reactive protein (CRP), procalcitonin, white blood cell (WBC) count, and red blood cell (RBC) count are evaluated to rule out other diseases [8].…”

Section: Introductionmentioning

confidence: 99%

“…Low levels of platelet count and high MPV values were observed. Inflammatory markers, such as CRP and erythrocyte sedimentation rate (ESR) appear to be elevated [9][10][11][12][13][14][15]. Inflammatory mechanisms play a major role in the etiology of vascular diseases.…”

Section: Introductionmentioning

confidence: 99%

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Association between common laboratory indices and IgAV recurrence in children

Zhou

Luo

et al. 2022

BMC Pediatr

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Background IgA vasculitis (IgAV) is a common type of vasculitis seen in children. IgAV recurrence can result in chronic kidney disease. We aimed to explore the association between common laboratory indices and IgAV recurrence in children, and to establish a prediction model. Methods This retrospective study included children with diagnosed with IgAV hospitalized in Bazhong Central Hospital, Sichuan, from January 2014 to December 2019. Children were assigned to two groups based on IgAV recurrence, and baseline clinical data were collected for comparison. A logistic regression model to predict IgAV recurrence was established. The receiver operating characteristic curve was plotted. The area under the curve (AUC) was used to detect performance of the predictive model. Results This study included 193 children (39 [20.2%], recurrence group; 154 [79.8%], non-recurrence group). Based on multivariate regression analysis, the duration of illness and joint involvement were independent predictors of IgAV recurrence in children (P < 0.05). No significant differences were observed in common laboratory indices (P > 0.05). The AUC of the prediction model was 0.766 (P < 0.001) with sensitivity of 74.4% and specificity of 68.8%. Conclusion Common laboratory indices were not associated with recurrence of IgAV in children.

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IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis

Vivarelli,

Samuel,

Coppo

et al. 2024

Pediatr Nephrol

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IgA nephropathy and IgA vasculitis with nephritis, albeit rare, represent two relatively frequent glomerular conditions in childhood. Compared to adults, pediatric IgA nephropathy has a more acute presentation, most frequently with synpharyngitic macrohematuria and histologically with more intense inflammation and less intense chronic damage. Management of these conditions is controversial and supported by little high-quality evidence. The paucity of evidence is due to the disease heterogeneity, its inter-ethnic variability, and the difficulty of extrapolating data from adult studies due to the peculiarities of the condition in children. IgA vasculitis with nephritis is a kidney manifestation of a systemic disorder, typical of the pediatric age, in which both the diagnosis of kidney involvement and its management are poorly defined, and an interdisciplinary approach is crucial. Both conditions can have a profound and long-lasting impact on kidney function and the global health of affected children. The International Pediatric Nephrology Association has therefore convened a diverse international group of experts from different disciplines to provide guidance on the recommended management of these conditions in children and to establish common definitions and define priorities for future high-quality, evidence-based collaborative studies for the benefit of children.

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Predictive role of laboratory markers and clinical features for recurrent Henoch-Schönlein Purpura in childhood: A study from Turkey

Cited by 9 publications

References 19 publications

Gastrointestinal involvement in childhood vasculitides

Gastrointestinal involvement in childhood vasculitides

Association between common laboratory indices and IgAV recurrence in children

IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis

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