Predictive role of the homeostatic model of insulin resistance (HOMA-IR) in the population of residents of light iodine endemia

Abstract

TyumenStudy the gender aspects of the prognostic rank of the concentration of LP (a) and the high normal content of thyroid-stimulating hormone at risk for the development and progression of cardiovascular diseases in the population of mild iodine endemic residents according to a prospective observation (80 months). Materials and methods. 1501 people were examined, aged 49.25 ± 11.3 years (Me - 52 years, Q1-Q3 – 52; 59 years old), 29.91% of men (449/1501) and 70.09% of women (1052/1501) with excess body weight and obesity in 74.28% (1115/1502) and hypertension in 51.07% (766/1501). Results. In the group of study participants with IR ( ≥ 2.7), higher age, BMI, SBP, DBP, HDL cholesterol, TG, ApoA1, glucose, uric acid, CRP, FG and insulin. In general, in the population of inhabitants of mild iodine endemic, the risk of non-fatal cardiovascular events is associated with the presence of IR – χ2 = 4.36; p = 0.037. However, the prognostic significance of IR as a marker of CVR is confirmed exclusively in the group of females – χ2 = 5.7; p = 0.017, also significant strata are: age 51-55 – χ2 = 2.85; p = 0.092, age 56-60 years – χ2 = 10.68; p = 0.001, BMI ≥ 30 kg/m2 – χ2 = 4.46; p = 0.035, TG level < 1.7 mmol/L – χ2 = 5.19; p = 0.023, uric acid concentration < 360 mmol/l – χ2 = 4.83; p = 0.028. Conclusion. In the population of inhabitants of mild iodine endemicity, insulin resistance is associated with the risk of non-fatal cardiovascular events. At the same time, these associations are valid for females, persons in the age range 51-60 years old, obese patients, patients with a TG level of less than 1.7 mmol/L and a uric acid content of less than 360 mmol/L.