Predictive Role of the Neutrophil Lymphocyte Ratio for Invasion with Gestational Trophoblastic Disease

Güzel, Ali İrfan; Kokanali, Mahmut Kuntay; Erkılınç, Selçuk; Topçu, Hasan Onur; Öz, Murat; Özgü, Emre; Erkaya, Salım; Güngör, Tayfun

doi:10.7314/apjcp.2014.15.10.4203

Cited by 20 publications

(23 citation statements)

References 21 publications

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“…In a study RMI with a cut-off 150 was found to have a sensitivity of 84% and specificity of 97% in detecting ovarian cancer (ArunMuthuvel et al, 2014). NLR is a new and easy calculated marker that has been used in determining various cancers (Acmaz et al, 2014;Guzel et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Yeşilyurt¹,

Tokmak²,

Güzel³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: To evaluate factors for predicting the granulosa cell tumor of the ovary (GCTO) pre-operatively. Materials and Methods: This retrospective designed study was conducted on 34 women with GCTO as the study group and 76 women with benign ovarian cysts as the control group. Data were recorded from the hospital database and included age, body mass index (BMI), parity, serum estradiol (E 2 ) levels, diameter of the mass, ultrasonographic features, serum CA125 level, risk of malignancy index (RMI), duration of menopause, postoperative histopathology result, and the neutrophil/lymphocyte ratio (NLR). Results: The demographic parameters showed no statistically significant difference between the groups. Preoperative diameter of the mass, CA125, duration of menopause, and neutrophil/lymphocyte ratio were significantly different between the groups. ROC curve analysis demonstrated that diameter of the mass, serum estradiol and Ca125 levels, RMI and NLR may be discriminative factors in predicting GCTO preoperatively. Conclusions: In conclusion, we think that a careful preoperative workshop including diameter of the mass, serum estradiol (E 2 ) and Ca125 levels, RMI and NLR may predict GCTO and may prevent incomplete approaches.

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Section: Introductionmentioning

confidence: 99%

Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Yeşilyurt¹,

Tokmak²,

Güzel³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In studies in recent years, NLR and PLR are gaining increasing importance as a marker of systemic inflammatory response. They have been reported as a positive marker for many gynecological and obstetric diseases; endometriosis, endometrial cancer, pelvic inflammatory disease, premature birth, ovarian cancer, cervical cancer, gestational trophoblastic disease, endometrial hyperplasia, gestational diabetes, preeclampsia and uterine sarcomas [9][10][11][12][13][14][15][16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

Preoperative diagnostic value of hematologic inflammatory markers in ovarian torsion

Bacanakgıl¹,

Kaban²,

Hasanova³

et al. 2019

OBGYN

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Background: Ovarian torsion is a rare gynecologic emergency which diagnosis may be overlooked. Clinic is nonspecific, and there are no reliable laboratory methods to confirm the preoperative diagnosis. Usually, the diagnosis is confirmed during surgery. Objective: The aim of the study is to investigate the availability of diagnostic value neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and plateletcrit (PCT) values of ovarian torsion cases. Methodology: The preoperative hematologic values of 36 ovarian torsion cases which were operated and histopathologically confirmed were compared with 135 control cases. Results: NLR value of the study group was significantly higher than the control group (p=0.001). There were no significant difference in PLR and PCT values (p>0.05). Cut-off value of the NLR was found to be 3.10. This value corresponds to 83.33% sensitivity, 84.44% specificity, 58.80% positive predictive value (PPV) and 95% negative predictive value (NPV). Conclusion: Three and above value of NLR can be used as a hematological marker for the diagnosis of ovarian torsion.

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“…35 In another study which is published in 2014, it has been suggested that neutrophil/lymphocyte ratio can be used as a biomarker for invasion in gestational trophoblastic diseases. 36 The value of inflammatory cell counts obtained from hemogram are investigated in this study. According to this study it is suggested that the mean number of statistically significant lymphocyte counts between the control group and the HM group can be confirmed in a larger series of patients and that it may contribute to the routine management and diagnosis of the patient with the other markers mentioned in the literature.…”

Section: Discussionmentioning

confidence: 99%

Predictivity of inflammatory cell counts in early diagnosis of hydatidiform mole

Eroğlu

Adalı

2019

Int J Res Med Sci

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Background: Hydatidiform mole (HM) is the most frequently encountered disease among gestational trophoblastic diseases. HM can invade myometrium and result in hysterectomy and because of the absence of any predictive method, the disease can be lately diagnosed in the periphery. Author aimed to evaluate predictive value of the inflammatory cell counts in molar pregnancies in this study.Methods: Nineteen (19) cases with histopathologic HM diagnosis and 19 cases of control group with pregnancy termination or abortion material reached to a university hospital's pathology department on the same day were included in the study. The data on the same day or the day before the operation was used as the hemogram data.Results: The mean age of the cases were 33.84±8.477. The mean of neutrophil, lymphocyte, monocyte, basophil and eosinophil numbers of the HM group and control group were compared in the 95% confidence interval with the independent t test. No statistical significance was observed in any of the inflammatory cell means (p>0.05). The ratio of lymphocyte means was statistically significant (p=0.006).Conclusions: In this study, author assessed whether the inflammatory cell counts were a predictive in detecting HM. The statistically significant results that author founded in the means of lymphocyte, suggests that this finding may be predictive of early diagnosis. They concluded that this result can be routinely used after the confirmation of the results in larger series of cases.

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Predictive Role of the Neutrophil Lymphocyte Ratio for Invasion with Gestational Trophoblastic Disease

Cited by 20 publications

References 21 publications

Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Preoperative diagnostic value of hematologic inflammatory markers in ovarian torsion

Predictivity of inflammatory cell counts in early diagnosis of hydatidiform mole

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