Predictive significance of lymphocyte level and neutrophil‐to‐lymphocyte ratio values during radiotherapy in cervical cancer treatment

Abstract

ObjectiveThe objective of this research was to analyze the prognostic significance of the minimum count of lymphocytes (LY) and the corresponding ratio of neutrophil‐to‐lymphocyte (NLR) in cervical cancer (CC) patients receiving radiotherapy.MethodsWe retrospectively collected data from 202 CC patients who received concurrent chemoradiotherapy or radiotherapy alone at our hospital. Statistical methods including the Kaplan–Meier method, log‐rank test and the Cox proportional hazards model were included to examine survival differences and identify independent factors that may affect overall survival (OS) and progression‐free survival (PFS).ResultsThe research enrolled a total of 202 patients. Patients with higher LY levels and lower NLR values during radiotherapy had significantly better survival prognosis than those with lower LY levels and higher NLR values. Multivariate COX regression analysis revealed that FIGO stage I, pathological types of SqCC, absence of lymph node metastasis, concurrent chemoradiotherapy, higher LY levels during radiotherapy, and lower NLR values before radiotherapy were independently associated with poorer PFS. Similarly, FIGO stage I, absence of lymph node metastasis and lower NLR values during and before radiotherapy were independently linked with poorer OS.ConclusionMinimum LY value and its corresponding NLR during radiotherapy serve as prognostic factors for CC.

Vitamin D3 (Calcitriol) Monotherapy Decreases Tumor Growth, Increases Survival, and Correlates with Low Neutrophil-to-Lymphocyte Ratio in a Murine HPV-16-Related Cancer Model

“…A noteworthy observation from our study is the correlation observed between tumor size and inflammatory parameters, particularly the neutrophil-to-lymphocyte ratio (NLR). The NLR serves as a valuable biomarker for systemic inflammation and has been implicated in various diseases, including cancer [ 35 ]. In our study, we found that treatment with calcitriol monotherapy, and in combination with cisplatin, led to a significant reduction in NLR values.…”

“…On the other hand, the neutrophil-to-lymphocyte ratio (NLR) is an attractive biomarker of systemic inflammation because it is easily calculated, reproducible, and inexpensive [ 33 ]. This is a reliable prognostic marker of survival, regardless of tumor stage or disease in multiple tumor types such as colorectal, gastric, pancreatic, hepatic, pulmonary, renal, and ovarian, among others [ 34 , 35 ]. In cancer patients, an elevated NLR value correlates with patients with more advanced or aggressive disease with a higher tumor stage and metastatic lesions [ 34 , 36 ].…”

Clinical utility of the prognostic nutritional index in patients with metastatic hormone‐sensitive prostate cancer: A retrospective, multicenter, cohort study

“…A decreased Alb level was an independent predictor of poor survival in patients who underwent radical cystectomy 23 . In addition, the absolute lymphocyte count was explored as a predictor together with the neutrophil‐to‐lymphocyte ratio (NLR) in 202 patients with cervical cancer undergoing radiotherapy 24 . Although both an elevated lymphocyte count and a decreased NLR were related to shorter PFS, only the NLR was correlated with OS 24 .…”

“…In addition, the absolute lymphocyte count was explored as a predictor together with the neutrophil‐to‐lymphocyte ratio (NLR) in 202 patients with cervical cancer undergoing radiotherapy 24 . Although both an elevated lymphocyte count and a decreased NLR were related to shorter PFS, only the NLR was correlated with OS 24 . Based on previous reports, more studies have shown the significance of combined markers than of a single parameter, which may be useful in predicting prognosis.…”

“…24 Although both an elevated lymphocyte count and a decreased NLR were related to shorter PFS, only the NLR was correlated with OS. 24 Based on previous reports, more studies have shown the significance of combined markers than of a single parameter, which may be useful in predicting…”