Predictive Value of 99MTC-hynic-toc Scintigraphy in Lung Neuroendocrine Tumor Diagnosis

Boutsikou, Efimia; Porpodis, Κonstantinos; Chatzipavlidou, Vasiliki; Hardavella, Georgia; Gerasimou, George; Domvri, Kalliopi; Papadopoulos, Nikitas; Avramidou, Vasiliki; Spyratos, Dionisis; Kontakiotis, Theodoros; Zarogoulidis, Konstantinos

doi:10.1177/1533033819842586

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…This is in accordance with our results considering grade and stage of our investigated patients. Similar to our findings, SRS nor the Krenning score in SRS in general did not relate significantly to progression-free survival[ 29 ] nor can be used as prognostic markers.…”

Section: Discussionsupporting

confidence: 88%

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Saponjski

Macut

Šobić-Šaranović

et al. 2020

WJCC

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BACKGROUND Neuroendocrine tumors of appendix (ANETs) known as carcinoids, are rare endocrine neoplasms originated from enterochromaffin cells of gastrointestinal tract. ANETs are the third most frequent (16.7%) gastrointestinal neuroendocrine tumors, with the incidence of 0.08-0.2 cases/100000 during one year. Incidental ANETs occur in 0.2%-0.7% of emergency surgical resections because of suspected appendicitis which is usually the first manifestation of ANET. Although there are a lot of papers about application of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumors, there are very rare sporadic cases described about ANETs particularly. AIM To establish the role of somatostatin receptor scintigraphy (SRS) in the management of patients with neuroendocrine tumors of appendix (ANET). METHODS The total of 35 patients was investigated, 23 females and 12 males, average age (43.7 ± 17.3 years). All patients had histological diagnosis of ANET (34 carcinoids of appendix and one tubular carcinoid). Majority of tumors have been found incidentally during surgery of: Acute appendicitis ( n = 15), perforated appendicitis ( n = 2), ileus ( n = 3), hysterectomy ( n = 3), ruptured ovarian cyst ( n = 2), caecal volvulus ( n = 1), while 9 patients had diagnosis of appendiceal tumor before the surgery. Seventeen patients had tumor grade (G) G1, 12 G2 and 6 G3. The right hemicolectomy was performed in 13, while the rest of the patients had appendectomy only. SRS was done early (2 h) and late (24 h) after i.v . application of 740 MBq technetium-99m ethylenediamine-N, N'-diacetic acid Hydrazinonicotinyl-Tyr3-Octreotide (technetium-99m-Tektrotyd, Polatom, Poland). SRS was performed for restaging in all the patients after surgery. RESULTS There were 12 true positive (TP), 19 true negative, 3 false positive and 1 false negative SRS result. Sensitivity of the method was 92.31%, specificity was 86.36%, positive predictive value was 80.00%, negative predictive value was 95.00% and accuracy 88.57%. Receiver operating characteristics analysis showed that SRS scintigraphy is a good test for detection TP cases [area under the curve of 0.850, 95% confidence interval (CI): 0.710-0.990, P < 001]. Single photon emission computed tomography contributed diagnosis in 7 TP findings. In 10 patients Krenning score was 4 and in 2 was 3. In 8 patients SRS significantly changed the management of the patients (in two surgery was repeated, in 4 somatostatin analogues and in two peptide receptor radionuclide therapy). Median progression-free survival in SRS positive patients was 52 months (95%CI: 39.7-117.3 mo) while in SRS negative patients it was 60 months (95%CI: 42.8-77.1 mo), without statistically significant differe...

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Section: Discussionsupporting

confidence: 88%

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Saponjski

Macut

Šobić-Šaranović

et al. 2020

WJCC

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“…This imaging technique is used in identifying primary LNETs as well as local and distant metastasis. 99mTc-Tektrotyd has a high affinity for somatostatin receptors, making it a markedly improved option in detecting well-differentiated NETs (67). However, for low-grade NETs, 68Ga-DOTANOC positron emission tomography (PET-CT) is markedly more sensitive.…”

Section: Radiological Diagnosismentioning

confidence: 99%

Lung neuroendocrine tumors: A systematic literature review (Review)

et al. 2021

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Neuroendocrine tumors (NETs) can have multiple localizations in the human body however, most often, it appears in the in thorax at tracheobronchial tree and the thymus. NETs are a group of tumors with heterogenous malignancy that evolve from neuroendocrine cells, with the lung being the second target organ after the gastrointestinal tract. These rare tumors are usually asymptomatic and non-functional with little information regarding incidence in the specialty literature. The main purpose of this review, was the analysis of the available literature in all aspects while mainly focusing on molecular diagnosis data and secondly, by using this molecular landscape to establish a differentiation of lung neuroendocrine tumors (LNETs). By analyzing the literature, new data were revealed regarding histological evaluation, genetic aberrations, prognosis depending on the type of LNET and therapeutic options that derive from these. Efficient management of these tumors is essential in the handling of symptoms and increase in life expectancy, especially in patients with functional tumors. Histological differentiation of LNETs is important in establishing proper therapeutic options and prognosis. Combined types of LNETs remain a controversial topic of discussion regarding diagnosis and treatment, a topic on which further studies are required in order to improve diagnosis in this group of tumors with heterogenous malignancy. Contents1. Introduction 2. Materials and methods 3. Epidemiology 4. Classification 5. Precursor lesions 6. Clinical features 7. Tumor staging 8. Biological landscape of lung neuroendocrine tumors (LNETs) 9. Radiological diagnosis 10. Surgical treatment 11. Advanced LNETs therapy 12. Conclusions

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“…Radiopharmaceuticals labeled with 99mTc were developed posteriorly, aiming to use gamma-emitting isotopes of higher image quality and easier handling. The [99mTc] EDDA-HYNIC-Thr3-octreotide (Tektrotyd ® ), represents an alternative to Octreoscan ® adding several advantages such as lower effective dose, easier preparation and speed in the acquisition of the study [ 15 , 16 ] ( Figure 3 ).…”

Section: Somatostatin Receptors As Targets For Imaging Diagnosis On Neuroendocrine Neoplasmsmentioning

confidence: 99%

Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

et al. 2021

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Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatostatin have been a large subject of interest in the discovery of potential biomarkers and treatment options for the disease. The aim of this review is to describe the molecular characteristics of somatostatin and somatostatin receptors and its application in diagnosis and therapy on patients with NENs as well as the use in the near future of somatostatin antagonists.

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Predictive Value of 99MTC-hynic-toc Scintigraphy in Lung Neuroendocrine Tumor Diagnosis

Cited by 6 publications

References 44 publications

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Lung neuroendocrine tumors: A systematic literature review (Review)

Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

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