Predictive Value of Cervical Length Measurement and Fibronectin Testing in Threatened Preterm Labor

Baaren, Gert Jan Van; Vis, Jolande Y.; Wilms, Femke F.; Oudijk, Martijn A.; Kwee, Anneke; Porath, Martina; Oei, Guid; Scheepers, Hubertina C.J.; Spaanderman, Marc E. A.; Bloemenkamp, Kitty W. M.; Haak, Monique C.; Bolte, Antoinette C.; Bax, Caroline J.; Cornette, Jérôme; Duvekot, Johannes J.; Bijvanck, Bas W.A. Nij; Eyck, Jim van; Franssen, Maureen; Sollie, Krystyna M.; Vandenbussche, Frank P.H.A.; Woiski, Mallory; Grobman, William A.; Post, Joris A. M. van der; Bossuyt, Patrick M.; Opmeer, Brent C.; Mol, Ben Willem J.

doi:10.1097/aog.0000000000000229

Cited by 103 publications

(38 citation statements)

References 18 publications

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“…There is often warning of impending preterm delivery, and interventions can be considered that might prolong gestation or reduce the risk of an adverse outcome by ‘preparing' the fetus, or enabling transfer to a centre with more experience of dealing with problems of prematurity. Cervical length measurement, in combination with fetal fibronectin testing, can help to determine which women are at low risk of delivery within 7 days, and perhaps allow a more judicious use of antenatal treatments [11]. Extremely preterm babies at risk of RDS should be born in centres where appropriate skills are available, as long-term health outcomes are better if they receive their initial neonatal care in tertiary units [12].…”

Section: Prenatal Carementioning

confidence: 99%

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update

et al. 2016

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Advances in the management of respiratory distress syndrome (RDS) ensure that clinicians must continue to revise current practice. We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe. Methods for optimal delivery room management have become more evidence based, and protocols for lung protection, including initiation of continuous positive airway pressure and titration of oxygen, should be implemented from soon after birth. Surfactant replacement therapy is a crucial part of the management of RDS, and newer protocols for surfactant administration are aimed at avoiding exposure to mechanical ventilation, and there is more evidence of differences among various surfactants in clinical use. Newer methods of maintaining babies on non-invasive respiratory support have been developed and offer potential for greater comfort and less chronic lung disease. As technology for delivering mechanical ventilation improves, the risk of causing lung injury should decrease although minimizing the time spent on mechanical ventilation using caffeine and if necessary postnatal steroids are also important considerations. Protocols for optimizing the general care of infants with RDS are also essential with good temperature control, careful fluid and nutritional management, maintenance of perfusion and judicious use of antibiotics all being important determinants of best outcome.

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Section: Prenatal Carementioning

confidence: 99%

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update

et al. 2016

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“…Several studies, including our nationwide cohort study, have reported promising results of the combination of cervical length and fetal fibronectin measurements to predict preterm delivery within 7 days in symptomatic women [2,11,12]. It is possible that predictions will improve even further when other prognostic features are added to these two measures.…”

Section: Introductionmentioning

confidence: 89%

“…Several studies have reported promising results of combining cervical length and fetal fibronectin measurements to predict spontaneous preterm delivery in symptomatic women, including our own APOSTEL-1 study [2,11,12]. Measuring cervical length and fetal fibronectin has been shown cost-effective by reducing unnecessary healthcare costs without compromising neonatal outcome [27,28].…”

Section: Commentmentioning

confidence: 96%

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Risk factors for preterm delivery: do they add to fetal fibronectin testing and cervical length measurement in the prediction of preterm delivery in symptomatic women?

Baaren

Bruijn

Vis

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Weiterer Marker, die physiologische von behandlungsbedürftiger Wehentä-tigkeit differenzieren können [11][12][13], sind 4 fetales Fibronektin (fFN), 4 plazentares α-Mikroglobulin-1 (PAMG-1)und 4 phosphoryliertes pIGFBP-1 ("insulin-like growth factor binding protein-1"). …”

Section: Indikation Zur Wehenhemmungunclassified

Tocolysis – update 2016

et al. 2016

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Predictive Value of Cervical Length Measurement and Fibronectin Testing in Threatened Preterm Labor

Abstract: II.

Cited by 103 publications

References 18 publications

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update

Risk factors for preterm delivery: do they add to fetal fibronectin testing and cervical length measurement in the prediction of preterm delivery in symptomatic women?

Tocolysis – update 2016

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