Predictive value of combining leucocyte and platelet counts for mortality in ST-segment elevation myocardial infarction patients after percutaneous coronary intervention treatment in Chinese population: a retrospective cohort study

Abstract

ObjectiveRisk stratification is challenging in patients with acute ST segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI). We investigated the prognostic value of a novel score system combining leucocyte and platelet counts (COL-P) scores for in-hospital and long-term adverse outcomes.DesignThis was a retrospective cohort study of patients with STEMI.SettingFirst Affiliated Hospital of Xinjiang Medical University.ParticipantsA total of 854 STEMI patients with primary PCI were included in this study from November 2009 and December 2015.Primary and secondary outcome measuresMajor adverse cardiovascular events (MACEs).MethodologyThe patients were divided into three groups according to the COL-P scores (0, 1 and 2). Cox regression analysis was used to investigate the relation between adverse outcomes and the COL-P score in patients with STEMI.ResultsA total of 44 patients died in hospital, and 99 within 3-year follow-up after discharge. The in-hospital and 3-year mortality and MACEs were higher in patients with higher COL-P score. Multivariable Cox regression indicated COL-P score was independently associated with long-term mortality (COL-P 1 vs COL-P 0: HR 2.07, 95% CI 1.016 to 5.567, p=0.005; COL-P 2 vs COL-P 0: HR 5.02, 95% CI 1.990 to 9.041, p<0.001).ConclusionThe COL-P score was a useful risk system for stratifying high-risk patients with STEMI after primary PCI.

To Gain Insights into the Pathophysiological Mechanisms of the Thrombo-Inflammatory Process in the Atherosclerotic Plaque

“…Of these, 5-HT (serotonin) is of particular interest. In addition to inducing vasoconstriction, 5-HT also amplifies platelet and endothelial activation, as evidenced by its ability to facilitate Weibel-Palade body exocytosis [ 15 , 45 , 46 ]. (Etulain and colleagues proposed that platelets induce neutrophils to release neutrophil extracellular traps (NETs) via P-selectin and PSGL-1 signals during aseptic inflammation) [ 47 ].…”