Predictive value of coronary artery dilation response to nitrate for a positive intracoronary acetylcholine provocation test

Saito, Yuichi; Kitahara, Hideki; Shoji, Toshihiro; Tokimasa, Satoshi; Nakayama, Takashi; Sugimoto, Kazumasa; Fujimoto, Yoshihide; Kobayashi, Yoshio

doi:10.1097/mca.0000000000000401

Cited by 3 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with the previous studies 9 , 10 , our study has several advantages. First, our analysis was conducted with a relatively large number of patients who were enrolled consecutively.…”

Section: Discussionmentioning

confidence: 87%

“…In this regard, some researchers have introduced simpler methods for the diagnosis of vasospastic angina. In one retrospective study, the predictive value of NID for a positive acetylcholine provocation test was evaluated 9 . The authors of this study concluded that NID is a possible predictor for a positive result of the acetylcholine provocation test.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic and prognostic role of nitroglycerin-induced dilation in patients with suspected vasospastic angina, combined with ergonovine provocation test

Kim

Jang

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The diagnostic and prognostic role of nitroglycerin-induced dilation (NID) combined with ergonovine provocation test in patients with suspected VSA patients is not clear. A total of 438 consecutive patients who underwent the ergonovine provocation test for the diagnosis of vasospastic angina (VSA) were enrolled. Patients with VSA (n = 52) had a significantly greater coronary response to ergonovine (− 84.3 ± 10.5% vs. − 38.4 ± 17.9%, p < 0.001) and NID (26.3 ± 31.0% vs. 12.5 ± 19.0%, p < 0.001) than non-VSA patients. However, positive NID (more than 13.8% dilation, n = 170) showed a poor accuracy (AUC 0.64 [95% CI: 0.56–0.73], p = 0.001, sensitivity 60.4%, specificity 61.3%) for the diagnosis of VSA by ergonovine provocation test. Major adverse cardiovascular events (MACE) occurred more frequently in the VSA group than in the non-VSA group (9.6% vs. 2.2%, p = 0.006). In addition, the positive NID group showed a lower rate of MACE than the negative NID group (1.2% vs. 4.3%, p = 0.021). Interestingly, the group of VSA with negative NID had poor prognosis than any other combinations (Log-rank, p < 0.0001). Although NID had a limited role in the detection of VSA defined by ergonovine provocation test, NID combined with the ergonovine provocation test has an additive prognostic role in the clinical outcomes in patients with suspected VSA.

show abstract

“…Compared with the previous studies 9 , 10 , our study has several advantages. First, our analysis was conducted with a relatively large number of patients who were enrolled consecutively.…”

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%