Predictive value of cystatin C in people with suspected or established coronary artery disease: A meta-analysis

Yang, Shaohui; Song, Luorui; Zhao, Lei; Dong, Pingshuan; Lai, Lihong; Wang, Honglei

doi:10.1016/j.atherosclerosis.2017.05.025

Cited by 24 publications

(14 citation statements)

References 33 publications

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“…found an increased mortality in CAD patients with elevated cystatin C levels [25]. High level of Cystatin C and risk of mortality and morbidity had also been revealed in other different cohorts [26][27][28][29]. Our current study results strongly implied that the serum level of cystatin C may be a promising biomarker for the evaluation of atherosclerotic plaque burden.…”

Section: Discussionsupporting

confidence: 78%

Significant association between Cystatin C, Gensini score, and Potential biomarker for Increased Risk of coronary artery lesions

pan

Chen

Zhou

et al. 2020

Preprint

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Objective: Cystatin C (Cys C) has been proposed as a useful biomarker of early impaired kidney function and predictor of mortality risk. The present analysis is to investigate the association of serum Cystatin C with the severity of coronary artery lesions, Gensini score (GS) and the risk of CAD.Methods: 682 CAD patients (230 females, 452 males; mean age 62.6±10.7 years, range from 31 to 86 years) and 135 healthy controls (41 females, 94 males; mean age 58.0±10.3 years, range from 38 to 84 years) were recruited in the current study. ELISA was applied to measure serum Cystatin C levels. Estimated glomerular filtration rate (eGFR) and Gensini score were calculated. Results: Serum TC, LDL-C, UA, Cystatin C and HCY were significantly elevated in CAD patients compared to healthy controls. There were significant differences regarding to Cystatin C, eGFR and Gensini score among different type of CAD patients, of which AMI group had an elevated serum Cystatin C, LDL-C, HCY and Gensini score than the other two groups. When stratified by the quartiles of Cystatin C, we found that age, proportion of male patients and hypertension and diabetes, HCY and Gensini score were increased in Quartile fourth groups than in other quartile groups. Spearman's correlation test revealed positive relationship between Cystatin C, HCY and Gensini score. Multivariate logistic regression analysis revealed that serum Cystatin C level, presence of hypertension and diabetes, HCY, age and male were the risk factors for coronary artery lesions.Conclusions: In summary, our results suggested that Cystatin C is a promising clinical biomarker that provides complementary information to the established risk determinants. The serum Cystatin C level is strongly associated with Gensini score and could be used to evaluate the severity of coronary artery lesions.

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Section: Discussionsupporting

confidence: 78%

Significant association between Cystatin C, Gensini score, and Potential biomarker for Increased Risk of coronary artery lesions

pan

Chen

Zhou

et al. 2020

Preprint

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“…In our ex vivo study on plasma samples from ICU patients, a panel of 43 cytokines and coagulation factors was examined, and only TPA and cystatin C were associated with mortality risk ( 47 – 52 ). TPA is involved with fibrinolysis and has been reported to be a marker for subsequent mortality in subjects hospitalized for acute dyspnea ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

“…Its significant release by endothelial cells after traumatic injury has been shown to result in excessive bleeding and hyperfibrinolysis, which are known risk factors for mortality ( 48 , 49 ). Cystatin C is a cysteine protease inhibitor that plays a role in catabolism of proteins, and it has been widely described as being associated with mortality risk in various disease states ( 47 , 51 , 52 ). In addition, 4 of the 14 EV markers tested were asso-ciated with increased death risk in this population of critically ill patients who primarily presented with medical as opposed to surgical diagnoses ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients

et al. 2018

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To understand how extracellular vesicle (EV) subtypes differentially activate monocytes, a series of in vitro studies were performed. We found that plasma-EVs biased monocytes toward an M1 profile. Culturing monocytes with granulocyte-, monocyte-, and endothelial-EVs induced several pro-inflammatory cytokines. By contrast, platelet-EVs induced TGF-β and GM-CSF, and red blood cell (RBC)-EVs did not activate monocytes in vitro. The scavenger receptor CD36 was important for binding of RBC-EVs to monocytes, while blockade of CD36, CD163, CD206, TLR1, TLR2, and TLR4 did not affect binding of plasma-EVs to monocytes in vitro. To identify mortality risk factors, multiple soluble factors and EV subtypes were measured in patients’ plasma at intensive care unit admission. Of 43 coagulation factors and cytokines measured, two were significantly associated with mortality, tissue plasminogen activator and cystatin C. Of 14 cellular markers quantified on EVs, 4 were early predictors of mortality, including the granulocyte marker CD66b. In conclusion, granulocyte-EVs have potent pro-inflammatory effects on monocytes in vitro. Furthermore, correlation of early granulocyte-EV levels with mortality in critically ill patients provides a potential target for intervention in management of the pro-inflammatory cascade associated with critical illness.

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“…21 Additionally, the predictive value of cystatin C in terms of all-cause mortality, cardiovascular mortality and total adverse vascular events was recently confirmed in people with suspected or established coronary artery disease. 22 Nevertheless, studies comparing the predictive value of creatinine- and cystatin C-based eGFR equations reported conflicting results. Indeed, predictivity of all-cause mortality was found to be far from optimum, with AUC ranging between 0.604 and 0.606, using CKD-EPI cre , CKD-EPI cys and CKD-EPI cre-cys in older women participating in the Calcium Intake Fracture Outcome Study, 23 whereas CKD-EPI cys and CKD-EPI cre-cys equations were found to better predict mortality compared with CKD-EPI cre and BIS cre-cys in older men enrolled in the Osteoporotic Fractures in Men Study.…”

Section: Discussionmentioning

confidence: 99%

Predicting survival of older community‐dwelling individuals according to five estimated glomerular filtration rate equations: The InChianti study

Corsonello

Pedone

Bandinelli³

et al. 2018

Geriatrics Gerontology Int

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Predictive value of cystatin C in people with suspected or established coronary artery disease: A meta-analysis

Cited by 24 publications

References 33 publications

Significant association between Cystatin C, Gensini score, and Potential biomarker for Increased Risk of coronary artery lesions

Significant association between Cystatin C, Gensini score, and Potential biomarker for Increased Risk of coronary artery lesions

Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients

Predicting survival of older community‐dwelling individuals according to five estimated glomerular filtration rate equations: The InChianti study

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